PROFILPELAJAR.COM

Adrenergički alfa-2B receptor
Identifikatori
Simboli	ADRA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR
Vanjski ID	OMIM: 104260 MGI: 87935 HomoloGene: 553 IUPHAR: α2B-adrenoceptor GeneCards: ADRA2B Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • adrenoceptorska aktivnost; • aktivnost alfa2-adrenergičkog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • interćelijska signalizacija;
Ortolozi

edit

Alfa-2B adrenergički receptor (α_2B adrenoceptor) je G-protein spregnuti receptor. On je tip adrenergičke receptorske familije. Humani gen koji kodira ovaj receptor ima simbol ADRA2B.^[1] ADRA2B ortolozi^[2] su identifikovani kod nekoliko sisara.

Receptor

Postoje tri visoko homologna tipa alfa-2-adrenergičkog receptora: alfa_2A, alfa_2B, i alfa_2C. Ti receptori učestvuju u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema.

Gen

Ovaj gen kodira alfa_2B tip receptora. On se vezuje za eIF-2B, faktor razmene guanin nukleotida koji učestvuje u regulaciji translacije. Za polimorfnu varijantu alfa_2B tip, kojoj nedostaju 3 glutaminske kiseline iz elementa ponavljanja glutaminskih kiselina, je ustanoljeno da ima umanjenu GPCR kinazama-posredovanu fosforilaciju i desenzitizaciju. Ova polimorfna forma je isto tako povezana sa umanjenom bazalnim metabolizmom kod gojaznih osoba i moguće je da doprinosi patogenezi gojaznosti. Ovaj gen ne sadrži introne.^[1]

Selektivni ligandi

Antagonisti

Povezano

Adrenergički receptor

Reference

Literatura

Lomasney JW, Lorenz W, Allen LF, et al. (1990). „Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.”. Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094–8. DOI:10.1073/pnas.87.13.5094. PMC 54268. PMID 2164221.
McClue SJ, Milligan G (1990). „The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.”. FEBS Lett. 269 (2): 430–4. DOI:10.1016/0014-5793(90)81209-7. PMID 2169434.
Weinshank RL, Zgombick JM, Macchi M, et al. (1990). „Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.”. Mol. Pharmacol. 38 (5): 681–8. PMID 2172775.
Chang AC, Ho TF, Chang NC (1990). „In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.”. Biochem. Biophys. Res. Commun. 172 (2): 817–23. DOI:10.1016/0006-291X(90)90748-C. PMID 2173582.
Regan JW, Kobilka TS, Yang-Feng TL, et al. (1988). „Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.”. Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301–5. DOI:10.1073/pnas.85.17.6301. PMC 281957. PMID 2842764.
Petrash AC, Bylund DB (1986). „Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.”. Life Sci. 38 (23): 2129–37. DOI:10.1016/0024-3205(86)90212-2. PMID 3012234.
Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). „A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.”. J. Biol. Chem. 272 (31): 19099–102. DOI:10.1074/jbc.272.31.19099. PMID 9235896.
Okusa MD, Huang L, Momose-Hotokezaka A, et al. (1998). „Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.”. Am. J. Physiol. 273 (6 Pt 2): F883–91. PMID 9435676.
Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). „The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.”. J. Biol. Chem. 274 (19): 13462–9. DOI:10.1074/jbc.274.19.13462. PMID 10224112.
Heinonen P, Koulu M, Pesonen U, et al. (1999). „Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”. J. Clin. Endocrinol. Metab. 84 (7): 2429–33. DOI:10.1210/jc.84.7.2429. PMID 10404816.
Hein L, Altman JD, Kobilka BK (2000). „Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.”. Nature 402 (6758): 181–4. DOI:10.1038/46040. PMID 10647009.
Small KM, Brown KM, Forbes SL, Liggett SB (2001). „Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.”. J. Biol. Chem. 276 (7): 4917–22. DOI:10.1074/jbc.M008118200. PMID 11056163.
Snapir A, Mikkelsson J, Perola M, et al. (2003). „Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.”. J. Am. Coll. Cardiol. 41 (2): 190–4. DOI:10.1016/S0735-1097(02)02702-X. PMID 12535806.
Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, et al. (2004). „The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.”. Clin. Auton. Res. 13 (3): 203–7. DOI:10.1007/s10286-003-0087-5. PMID 12822042.
Chotani MA, Mitra S, Su BY, et al. (2004). „Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.”. Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59–67. DOI:10.1152/ajpheart.00268.2003. PMID 12946937.
Von Wowern F, Bengtsson K, Lindblad U, et al. (2004). „Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.”. Hypertension 43 (3): 592–7. DOI:10.1161/01.HYP.0000116224.51189.80. PMID 14744925.
Cayla C, Heinonen P, Viikari L, et al. (2004). „Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.”. Biochem. Pharmacol. 67 (3): 469–78. DOI:10.1016/j.bcp.2003.09.029. PMID 15037199.
Phares DA, Halverstadt AA, Shuldiner AR, et al. (2004). „Association between body fat response to exercise training and multilocus ADR genotypes.”. Obes. Res. 12 (5): 807–15. DOI:10.1038/oby.2004.97. PMID 15166301.
Siitonen N, Lindström J, Eriksson J, et al. (2005). „Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.”. Diabetologia 47 (8): 1416–24. DOI:10.1007/s00125-004-1462-z. PMID 15309292.
Belfer I, Buzas B, Hipp H, et al. (2005). „Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.”. J. Hum. Genet. 50 (1): 12–20. DOI:10.1007/s10038-004-0211-y. PMID 15592690.

Spoljašnje veze

„α_2B-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-05.