Kortikotropin-oslobađajući hormonski receptor

Kortikotropin-oslobađajući hormonski receptor 1
Identifikatori
Simbol CRHR1
Alt. simboli CRHR
Entrez 1394
HUGO 2357
OMIM 122561
RefSeq XM_001128344
UniProt P34998
Drugi podaci
Lokus Hromozom 17 q12-q22
Kortikotropin-oslobađajući hormonski receptor 2
Identifikatori
Simbol CRHR2
Entrez 1395
HUGO 2358
OMIM 602034
RefSeq NM_001883
UniProt Q13324
Drugi podaci
Lokus Hromozom 7 p21-p15

Kortikotropin-oslobađajući hormonski receptori (CRHR, receptori kortikotropin-oslobađajućeg faktora, CRFR) su familija G protein-spregnutih receptora koja vezuje kortikotropin-oslobađajući hormon (CRH).[1] Postoje dva receptora u ovoj grupi. Oni se obeležavaju kao tip 1 i 2, i kodirani su zasebnim genima (CRHR1 i CRHR2 respektivno).

Funkcija

CRHR proteini su posrednici responsa na stres.[2] Ćelije prednjeg režnja hipofize poznate kao kortikotropi izražavaju receptore i izlučuju adrenokortikotropni hormon (ACTH) nakon stimulacije.[3]

Literatura

  1. ↑ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). „International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands”. Pharmacol. Rev. 55 (1): 21–6. DOI:10.1124/pr.55.1.3. PMID 12615952. 
  2. ↑ Grammatopoulos DK, Chrousos GP (2002). „Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists”. Trends Endocrinol. Metab. 13 (10): 436–44. DOI:10.1016/S1043-2760(02)00670-7. PMID 12431840. 
  3. ↑ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). „Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system”. Neuroendocrinology 43 (1): 79–88. DOI:10.1159/000124513. PMID 3012395. 

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