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Gonadotropin-oslobađajući hormonski receptor
Identifikatori
Simboli	GNRHR; GNRHR1; GRHR; LHRHR; LRHR
Vanjski ID	OMIM: 138850 MGI: 95790 HomoloGene: 350 IUPHAR: GnRH GeneCards: GNRHR Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost; • aktivnost receptora gonadotropin oslobađajućeg hormona;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • razvoj multi-ćelijskog organisma;
Pregled RNK izražavanja
	podaci
Ortolozi

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GNRHR, Gonadotropin-oslobađajući hormonski receptor je protein koji je kod ljudi kodiran GNRHR genom.^[1]^[2]

Ovaj gen kodira tip 1 receptora gonadotropin oslobađajućeg hormona. Ovaj receptor je član familije sedam transmembranskih, G protein spregnutih receptora (GPCR). On je izražen na površini hipofiznih gonadotropnih ćelija kao i limfocita, dojki, jajnika, i prostate. Nakon vezivanja gonadotropin-oslobađajućeg hormona, receptor vezuje G-proteine koji aktiviraju sistem fosfatidilinozitol-kalcijumskih sekundarnih glasnika. Aktivacija receptora uzrokuje oslobađanje gonadotropnog luteinizirajućeg hormona (LH) i folikulostimulišućeg hormona (FSH). Defekti ovog gena uzrokuju hipogonadotropni hipogonadizam (HH). Alternativno splajsovanje rezultuje u višestrukim transkriptnim varijantama koje kodiraju različite izoforme. Više od 18 mesta inicijacije transkripcije u 5' regioni i više polyA signala u 3' regionu je identifikovano za ovaj gen.^[2]

Povezano

Literatura

↑ Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC (May 1993). „Cloning and characterization of the human GnRH receptor”. Mol Cell Endocrinol 91 (1-2): R1–6. DOI:10.1016/0303-7207(93)90278-R. PMID 8386108.
↑ ^2,0 ^2,1 „Entrez Gene: GNRHR gonadotropin-releasing hormone receptor”.

Dodatna literatura

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Vanjske veze

„Gonadotrophin-Releasing Hormone Receptors: GnRH receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.