LHCGR, luteinizirajući hormon/horiogonadotropinski receptor, lutropin/horiogonadotropinski receptor (LCGR) ili receptor luteinizirajućeg hormona (LHR), je transmembranski receptor nađen u jajnicima, testisima i ekstragonodalnim organima kao što je materica. Ovaj receptor interaguje sa luteinizirajućim hormonom (LH) i horionskim gonadotropinima (kao što je hCG kod čoveka). On je član familije G protein-spregnutih receptora. Njegova aktivacija je neophodna za funkcionisanje hormona tokom reprodukcije.
LHCGR gen
LHCGR gen je nađen na hromozomu 2 p21 kod ljudi, blizo gena FSH receptora. On se sastoji od 70 kbp (versus 54 kpb za FSHR).[1] Gen je sličan genima FSH i TSH receptora.
Struktura receptora
LHCGR se sastoji od 674 aminokiselina i ima molekulsku masu od oko 85–95 kDa u zavisnosti od stepena glikozilacije.[2]
LHCGR abnormalnosti
Mutacije koje dovode do gubitka funkcije ovog receptora mogu da dovedu do neplodnosti kod žena. Opsežna inaktivacija može da uzrokuje pseudohermafroditizam muškaraca, zbog odsustva responsa fetalnih Leidigovih ćelija i stoga indukuje maskulinizacije.[3] Inaktivacija manje jačine može da dovede do hipospadije ili do razvoja mikropenisa.[2]
↑Hirakawa, Takashi; Galet Colette, Kishi Mikiko, Ascoli Mario (December 2003). „GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR”. J. Biol. Chem. (United States) 278 (49): 49348–57. DOI:10.1074/jbc.M306557200. ISSN0021-9258. PMID14507927.
Dodatna literatura
Ji TH, Ryu KS, Gilchrist R, Ji I (1997). „Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor.”. Recent Prog. Horm. Res.52: 431–53; discussion 454. PMID9238862.
Ascoli M, Fanelli F, Segaloff DL (2002). „The lutropin/choriogonadotropin receptor, a 2002 perspective.”. Endocr. Rev.23 (2): 141–74. DOI:10.1210/er.23.2.141. PMID11943741.
Amsterdam A, Hanoch T, Dantes A, et al. (2003). „Mechanisms of gonadotropin desensitization.”. Mol. Cell. Endocrinol.187 (1-2): 69–74. DOI:10.1016/S0303-7207(01)00701-8. PMID11988313.
Fanelli F, Puett D (2003). „Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis.”. Endocrine18 (3): 285–93. DOI:10.1385/ENDO:18:3:285. PMID12450321.
Nagayama Y, Russo D, Wadsworth HL, et al. (1991). „Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.”. J. Biol. Chem.266 (23): 14926–30. PMID1651314.
Jia XC, Oikawa M, Bo M, et al. (1991). „Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species.”. Mol. Endocrinol.5 (6): 759–68. DOI:10.1210/mend-5-6-759. PMID1922095.
Minegishi T, Nakamura K, Takakura Y, et al. (1990). „Cloning and sequencing of human LH/hCG receptor cDNA.”. Biochem. Biophys. Res. Commun.172 (3): 1049–54. DOI:10.1016/0006-291X(90)91552-4. PMID2244890.
Rousseau-Merck MF, Misrahi M, Atger M, et al. (1991). „Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21.”. Cytogenet. Cell Genet.54 (1-2): 77–9. DOI:10.1159/000132962. PMID2249480.
Xie YB, Wang H, Segaloff DL (1991). „Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity.”. J. Biol. Chem.265 (35): 21411–4. PMID2254302.
Frazier AL, Robbins LS, Stork PJ, et al. (1991). „Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.”. Mol. Endocrinol.4 (8): 1264–76. DOI:10.1210/mend-4-8-1264. PMID2293030.
Latronico AC, Anasti J, Arnhold IJ, et al. (1995). „A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty.”. J. Clin. Endocrinol. Metab.80 (8): 2490–4. DOI:10.1210/jc.80.8.2490. PMID7629248.
Shenker A, Laue L, Kosugi S, et al. (1993). „A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty.”. Nature365 (6447): 652–4. DOI:10.1038/365652a0. PMID7692306.
Yano K, Saji M, Hidaka A, et al. (1995). „A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty.”. J. Clin. Endocrinol. Metab.80 (4): 1162–8. DOI:10.1210/jc.80.4.1162. PMID7714085.
Kremer H, Kraaij R, Toledo SP, et al. (1995). „Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene.”. Nat. Genet.9 (2): 160–4. DOI:10.1038/ng0295-160. PMID7719343.
Kosugi S, Van Dop C, Geffner ME, et al. (1995). „Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty.”. Hum. Mol. Genet.4 (2): 183–8. DOI:10.1093/hmg/4.2.183. PMID7757065.
Kremer H, Mariman E, Otten BJ, et al. (1994). „Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty.”. Hum. Mol. Genet.2 (11): 1779–83. DOI:10.1093/hmg/2.11.1779. PMID8281137.
Spoljašnje veze
„Glycoprotein Hormone Receptors: LH”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2021-01-18.