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G protein-spregnuti receptor 4
Identifikatori
Simboli	GPR4;
Vanjski ID	OMIM: 600551 MGI: 2441992 HomoloGene: 3867 IUPHAR: GPR4 GeneCards: GPR4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

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GPR4, G-protein spregnuti receptor 4, je protein koji je kod čoveka kodiran GPR4 genom.^[1]^[2]

Povezano

Proton-registrujući G protein-spregnuti receptori

Literatura

↑ Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (Apr 1996). „Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3”. Genomics 30 (1): 84–8. DOI:10.1006/geno.1995.0013. PMID 8595909.
↑ „Entrez Gene: GPR4 G protein-coupled receptor 4”.

Dodatna literatura

An S, Tsai C, Goetzl EJ (1996). „Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.”. FEBS Lett. 375 (1-2): 121–4. DOI:10.1016/0014-5793(95)01196-L. PMID 7498459.
Heiber M, Docherty JM, Shah G, et al. (1995). „Isolation of three novel human genes encoding G protein-coupled receptors.”. DNA Cell Biol. 14 (1): 25–35. DOI:10.1089/dna.1995.14.25. PMID 7832990.
Zhu K, Baudhuin LM, Hong G, et al. (2001). „Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.”. J. Biol. Chem. 276 (44): 41325–35. DOI:10.1074/jbc.M008057200. PMID 11535583.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lum H, Qiao J, Walter RJ, et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. DOI:10.1152/ajpheart.00359.2003. PMID 12805023.
Ludwig MG, Vanek M, Guerini D, et al. (2003). „Proton-sensing G-protein-coupled receptors.”. Nature 425 (6953): 93–8. DOI:10.1038/nature01905. PMID 12955148.
Bektas M, Barak LS, Jolly PS, et al. (2003). „The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.”. Biochemistry 42 (42): 12181–91. DOI:10.1021/bi035051y. PMID 14567679.
Sin WC, Zhang Y, Zhong W, et al. (2004). „G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.”. Oncogene 23 (37): 6299–303. DOI:10.1038/sj.onc.1207838. PMID 15221007.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim KS, Ren J, Jiang Y, et al. (2005). „GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.”. FASEB J. 19 (7): 819–21. DOI:10.1096/fj.04-2988fje. PMID 15857892.
Qiao J, Huang F, Naikawadi RP, et al. (2006). „Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.”. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. DOI:10.1152/ajplung.00508.2005. PMID 16461426.
Huang F, Mehta D, Predescu S, et al. (2007). „A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.”. Endothelium 14 (1): 25–34. DOI:10.1080/10623320601177288. PMID 17364894.
Zou Y, Kim CH, Chung JH, et al. (2007). „Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.”. FEBS J. 274 (10): 2573–84. DOI:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.
Tobo M, Tomura H, Mogi C, et al. (2007). „Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.”. Cell. Signal. 19 (8): 1745–53. DOI:10.1016/j.cellsig.2007.03.009. PMID 17462861.

[pmid8595909-1] Mahadevan MS, Baird S, Bailly JE, Shutler GG, Sabourin LA, Tsilfidis C, Neville CE, Narang M, Korneluk RG (Apr 1996). „Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3”. Genomics 30 (1): 84–8. DOI:10.1006/geno.1995.0013. PMID 8595909.

[entrez-2] „Entrez Gene: GPR4 G protein-coupled receptor 4”.

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