FZD5

Uvojiti receptor 5
Identifikatori
Simboli	FZD5; C2orf31; HFZ5
Vanjski ID	OMIM: 601723 MGI: 108571 HomoloGene: 2590 IUPHAR: FZD5 GeneCards: FZD5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora • receptorsko vezivanje • proteinsko vezivanje • Wnt proteinsko vezivanje • vezivanje PDZ domena
Celularna komponenta	• citoplazma • ćelijska površina • integralno sa membranom • sinaptosom • membrana neuronske projekcije
Biološki proces	• pozitivna regulacija proteinske fosforilacije • razvoj vaskulature • morfogeneza odlivnog trakta • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Uvojiti-5 je protein koji je kod ljudi kodiran FZD5 genom.^[1]^[2]^[3]

Reference

↑ Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J Biol Chem 271 (8): 4468–76. DOI:10.1074/jbc.271.8.4468. PMID 8626800.
↑ Saitoh T, Hirai M, Katoh M (Jun 2001). „Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region”. Int J Oncol 19 (1): 105–10. PMID 11408929.
↑ „Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)”.

Literatura

He X, Saint-Jeannet JP, Wang Y, et al. (1997). „A member of the Frizzled protein family mediating axis induction by Wnt-5A.”. Science 275 (5306): 1652–4. DOI:10.1126/science.275.5306.1652. PMID 9054360.
Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
Tamai K, Semenov M, Kato Y, et al. (2000). „LDL-receptor-related proteins in Wnt signal transduction.”. Nature 407 (6803): 530–5. DOI:10.1038/35035117. PMID 11029007.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). „Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.”. Genome Res. 11 (3): 422–35. DOI:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Yao R, Maeda T, Takada S, Noda T (2001). „Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.”. Biochem. Biophys. Res. Commun. 286 (4): 771–8. DOI:10.1006/bbrc.2001.5430. PMID 11520064.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Weidler C, Schaumburger J, Miller LE, et al. (2004). „Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation.”. J. Rheumatol. 31 (9): 1874–5. PMID 15338479.
Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). „Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.”. Biochem. Biophys. Res. Commun. 328 (2): 533–9. DOI:10.1016/j.bbrc.2005.01.009. PMID 15694380.
Hillier LW, Graves TA, Fulton RS, et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature 434 (7034): 724–31. DOI:10.1038/nature03466. PMID 15815621.
Blumenthal A, Ehlers S, Lauber J, et al. (2006). „The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.”. Blood 108 (3): 965–73. DOI:10.1182/blood-2005-12-5046. PMID 16601243.
Yamamoto H, Komekado H, Kikuchi A (2006). „Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.”. Dev. Cell 11 (2): 213–23. DOI:10.1016/j.devcel.2006.07.003. PMID 16890161.
Katoh Y, Katoh M (2007). „Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer.”. Int. J. Oncol. 30 (3): 751–5. PMID 17273778.

Povezano

Uvojiti receptori

Vanjske veze

„Frizzled Receptors: FZD₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-06-25.

[pmid8626800-1] Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). „A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled”. J Biol Chem 271 (8): 4468–76. DOI:10.1074/jbc.271.8.4468. PMID 8626800.

[pmid11408929-2] Saitoh T, Hirai M, Katoh M (Jun 2001). „Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region”. Int J Oncol 19 (1): 105–10. PMID 11408929.

[entrez-3] „Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)”.

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[2]

[3]

FZD5

Reference

Literatura

Povezano

Vanjske veze

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