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Receptor ukusa tip 2 član 8
Identifikatori
Simboli	TAS2R8; T2R8; TRB5
Vanjski ID	OMIM: 604794 HomoloGene: 88894 IUPHAR: GeneCards: TAS2R8 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa;
Celularna komponenta	• integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora; • hemosensorno ponašanje; • detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa;
Pregled RNK izražavanja
	podaci
Ortolozi

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Receptor ukusa tip 2 član 8 je protein koji je kod ljudi kodiran TAS2R8 genom.^[1]^[2]^[3]

Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Ovaj receptor ukusa ne sadrži introne. Njegov gen se nalazi na hromozomu 12p13.^[3]

Reference

↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). „A novel family of mammalian taste receptors”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934.
↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). „A family of candidate taste receptors in human and mouse”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242.
↑ ^3,0 ^3,1 „Entrez Gene: TAS2R8 taste receptor, type 2, member 8”.

Literatura

Kinnamon SC (2000). „A plethora of taste receptors”. Neuron 25 (3): 507–10. DOI:10.1016/S0896-6273(00)81054-5. PMID 10774719.
Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors”. Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

Povezano

Receptor ukusa

[pmid10761934-1] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). „A novel family of mammalian taste receptors”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934.

[pmid10766242-2] Matsunami H, Montmayeur JP, Buck LB (Apr 2000). „A family of candidate taste receptors in human and mouse”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242.

[entrez-3] 3,0 ^3,1 „Entrez Gene: TAS2R8 taste receptor, type 2, member 8”.

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