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Proteazom-aktivirani receptor 3
Identifikatori
Simboli	F2RL2; PAR3
Vanjski ID	OMIM: 601919 MGI: 1298208 HomoloGene: 36151 IUPHAR: PAR3 GeneCards: F2RL2 Gene
Ontologija gena
Molekularna funkcija	• odopsinu-slična receptorska aktivnost; • aktivnost fosfoinozitid fosfolipaze C; • receptorska aktivnost; • aktivnost trombinskog receptora;
Celularna komponenta	• membrana plazme; • integralno sa membranom plazme;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • koagulacija krvi; • respons na ranjavanje;
Pregled RNK izražavanja
	podaci
Ortolozi

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Proteazom-aktivirani receptor 3 (PAR3), ili Receptoru koagulacionog faktora II (trombina) sličan 2, je protein kodiran F2RL2 genom kod ljudi.

F2RL2 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR3 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor. F2RL2 je kofaktor za F2RL3 aktivaciju trombinom. On posreduje trombinom-podstaknutu fosfoinozitid hidrolizu. F2RL2 je izražen u nizu tkiva.^[1]

Povezano

Proteazom-aktivirani receptor

Reference

↑ „Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2”.

Literatura

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„Protease-Activated Receptors: PAR3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-04.