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Relaksinu/insulinu-slična familija, peptidni receptor 4
Identifikatori
Simboli	RXFP4; GPCR142; GPR100; MGC126556; MGC126558; RLN3R2
Vanjski ID	OMIM: 609043 MGI: 2182926 HomoloGene: 18775 IUPHAR: RXFP4 GeneCards: RXFP4 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost angiotenzin tip II receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Ortolozi

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RXFP4, relaksinu/insulinu-slična familija, peptidni receptor 4, je humani G-protein spregnuti receptor.^[1]

Ovaj receptor je ranije bio poznat pod nazivom GPR100.^[1]

Povezano

Relaksinski receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4”.

Literatura

Bathgate RA, Ivell R, Sanborn BM, et al. (2005). „Receptors for relaxin family peptides.”. Ann. N. Y. Acad. Sci. 1041: 61–76. DOI:10.1196/annals.1282.010. PMID 15956688.
Bathgate RA, Ivell R, Sanborn BM, et al. (2006). „International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.”. Pharmacol. Rev. 58 (1): 7–31. DOI:10.1124/pr.58.1.9. PMID 16507880.
Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1-3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu C, Chen J, Sutton S, et al. (2004). „Identification of relaxin-3/INSL7 as a ligand for GPCR142.”. J. Biol. Chem. 278 (50): 50765–70. DOI:10.1074/jbc.M308996200. PMID 14522967.
Boels K, Schaller HC (2004). „Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor.”. Br. J. Pharmacol. 140 (5): 932–8. DOI:10.1038/sj.bjp.0705521. PMC 1574110. PMID 14530218.
Fredriksson R, Höglund PJ, Gloriam DE, et al. (2003). „Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.”. FEBS Lett. 554 (3): 381–8. DOI:10.1016/S0014-5793(03)01196-7. PMID 14623098.
Liu C, Chen J, Kuei C, et al. (2005). „Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.”. Mol. Pharmacol. 67 (1): 231–40. DOI:10.1124/mol.104.006700. PMID 15465925.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu C, Kuei C, Sutton S, et al. (2005). „INSL5 is a high affinity specific agonist for GPCR142 (GPR100).”. J. Biol. Chem. 280 (1): 292–300. DOI:10.1074/jbc.M409916200. PMID 15525639.
Gregory SG, Barlow KF, McLay KE, et al. (2006). „The DNA sequence and biological annotation of human chromosome 1.”. Nature 441 (7091): 315–21. DOI:10.1038/nature04727. PMID 16710414.

Vanjske veze

„Relaxin Family Peptide Receptors: RXFP4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] 1,0 ^1,1 „Entrez Gene: RXFP4 relaxin/insulin-like family peptide receptor 4”.

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