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G protein-spregnuti receptor 37
Identifikatori
Simboli	GPR37; EDNRBL; PAELR; hET(B)R-LP
Vanjski ID	OMIM: 602583 MGI: 1313297 HomoloGene: 3875 IUPHAR: GPR37 GeneCards: GPR37 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost; • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

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GPR37, G protein-spregnuti receptor 37, je protein koji je kod čoveka kodiran GPR37 genom.^[1]^[2]

Interakcije

Za GPR37 je pokazano da interaguje sa HSPA1A^[3] i parkin ligazom.^[3]^[4]

Literatura

↑ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). „Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library”. Genomics 45 (1): 68–77. DOI:10.1006/geno.1997.4900. PMID 9339362.
↑ „Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)”.
↑ ^3,0 ^3,1 Imai, Yuzuru; Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke (July 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell (United States) 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. ISSN 1097-2765. PMID 12150907.
↑ Imai, Y; Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin”. Cell (United States) 105 (7): 891–902. DOI:10.1016/S0092-8674(01)00407-X. ISSN 0092-8674. PMID 11439185.

Dodatna literatura

Zeng Z, Su K, Kyaw H, Li Y (1997). „A novel endothelin receptor type-B-like gene enriched in the brain.”. Biochem. Biophys. Res. Commun. 233 (2): 559–67. DOI:10.1006/bbrc.1997.6408. PMID 9144577.
Donohue PJ, Shapira H, Mantey SA, et al. (1998). „A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.”. Brain Res. Mol. Brain Res. 54 (1): 152–60. DOI:10.1016/S0169-328X(97)00336-7. PMID 9526070.
Imai Y, Soda M, Inoue H, et al. (2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.”. Cell 105 (7): 891–902. DOI:10.1016/S0092-8674(01)00407-X. PMID 11439185.
Imai Y, Soda M, Hatakeyama S, et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.”. Mol. Cell 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. PMID 12150907.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang Y, Nishimura I, Imai Y, et al. (2003). „Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.”. Neuron 37 (6): 911–24. DOI:10.1016/S0896-6273(03)00143-0. PMID 12670421.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
Imai Y, Soda M, Murakami T, et al. (2004). „A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.”. J. Biol. Chem. 278 (51): 51901–10. DOI:10.1074/jbc.M309655200. PMID 14532270.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kubota K, Niinuma Y, Kaneko M, et al. (2006). „Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.”. J. Neurochem. 97 (5): 1259–68. DOI:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
Omura T, Kaneko M, Okuma Y, et al. (2007). „A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.”. J. Neurochem. 99 (6): 1456–69. DOI:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.