Somatostatin deluje na mnogim lokacijama i inhibira oslobađanje hormona i drugih sekretornih proteina. Biološki efekti somatostatina su posredovani familijom G protein-spregnutih receptora čije izražavanje je specifično za pojedina tkiva. SSTR4 u znatnoj meri izražen u mozgu fetusa i odraslih osoba, kao i u plućima.[2]
Demchyshyn LL, Srikant CB, Sunahara RK, et al. (1993). „Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.”. Mol. Pharmacol.43 (6): 894–901. PMID8100352.
Yasuda K, Espinosa R, Davis EM, et al. (1993). „Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.”. Genomics17 (3): 785–6. DOI:10.1006/geno.1993.1410. PMID8244401.
Yamada Y, Kagimoto S, Kubota A, et al. (1993). „Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.”. Biochem. Biophys. Res. Commun.195 (2): 844–52. DOI:10.1006/bbrc.1993.2122. PMID8373420.
Kaupmann K, Bruns C, Hoyer D, et al. (1993). „Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.”. FEBS Lett.331 (1-2): 53–9. DOI:10.1016/0014-5793(93)80296-7. PMID8405411.
Yamada Y, Stoffel M, Espinosa R, et al. (1993). „Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.”. Genomics15 (2): 449–52. DOI:10.1006/geno.1993.1088. PMID8449518.
Xu Y, Song J, Bruno JF, Berelowitz M (1993). „Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.”. Biochem. Biophys. Res. Commun.193 (2): 648–52. DOI:10.1006/bbrc.1993.1673. PMID8512564.
Fukusumi S, Kitada C, Takekawa S, et al. (1997). „Identification and characterization of a novel human cortistatin-like peptide.”. Biochem. Biophys. Res. Commun.232 (1): 157–63. DOI:10.1006/bbrc.1997.6252. PMID9125122.
de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). „Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.”. Genomics42 (3): 499–506. DOI:10.1006/geno.1997.4763. PMID9205124.
Jaïs P, Terris B, Ruszniewski P, et al. (1997). „Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.”. Eur. J. Clin. Invest.27 (8): 639–44. DOI:10.1046/j.1365-2362.1997.1740719.x. PMID9279525.
Sharma K, Patel YC, Srikant CB (1999). „C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.”. Mol. Endocrinol.13 (1): 82–90. DOI:10.1210/me.13.1.82. PMID9892014.
Zatelli MC, Tagliati F, Taylor JE, et al. (2001). „Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.”. J. Clin. Endocrinol. Metab.86 (5): 2161–9. DOI:10.1210/jc.86.5.2161. PMID11344221.
Pasquali D, Notaro A, Esposito D, et al. (2002). „[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]”. Minerva Endocrinol.26 (3): 175–9. PMID11753241.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature414 (6866): 865–71. DOI:10.1038/414865a. PMID11780052.
Papotti M, Bongiovanni M, Volante M, et al. (2002). „Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.”. Virchows Arch.440 (5): 461–75. DOI:10.1007/s00428-002-0609-x. PMID12021920.
Vanjske veze
„Somatostatin Receptors: sst4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
