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G protein-spregnuti receptor 44
Identifikatori
Simboli	GPR44; CD294; CRTH2
Vanjski ID	OMIM: 604837 MGI: 1330275 HomoloGene: 3508 IUPHAR: DP2 GeneCards: GPR44 Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • aktivnost prostaglandin J receptora; • receptorska aktivnost; • aktivnost prostaglandin D receptora; • aktivnost prostaglandin F receptora; • aktivnost N-formil peptidnog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• hemotaksa; • imunski respons; • prenos signala; • signalni put G-protein spregnutog receptora; • G-protein signalizacija, adenilat ciklazni inhibitorni put; • kalcijum-posredovana signalizacija; • pozitivna regulacija signalnog puta G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

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GPR44, G protein-spregnuti receptor 44, je protein koji je kod čoveka kodiran GPR44 genom.^[1] GPR44 se takođe naziva CD294 (klaster diferencijacije 294).

G protein spregnuti receptori, kao što je GPR44, su integralni membranski proteini koji sadrže 7 transmembranskih domena (TM). Ti protein posreduju prenos signala u unutrašnjost ćelije aktivacijom heterotrimernih G proteina koji zatim aktiviraju razne efektorske proteine, što ultimatno dovodi do fiziološkog responsa.^[1]

Za GPR44 je nedavno nađeno da pripada prostanoidnoj receptorskoj familiji i nazvan je DP₂, i to je njegovo zvanično IUPHAR ime.

Reference

↑ ^1,0 ^1,1 „Entrez Gene: GPR44 G protein-coupled receptor 44”.

Literatura

Nagata K (2004). „CRTH2.”. J. Biol. Regul. Homeost. Agents 17 (4): 334–7. PMID 15065763.
Chiba T, Kanda A, Ueki S, et al. (2007). „Possible novel receptor for PGD2 on human bronchial epithelial cells.”. Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. DOI:10.1159/000101400. PMID 17541272.
Nagata K, Tanaka K, Ogawa K, et al. (1999). „Selective expression of a novel surface molecule by human Th2 cells in vivo.”. J. Immunol. 162 (3): 1278–86. PMID 9973380.
Marchese A, Sawzdargo M, Nguyen T, et al. (1999). „Discovery of three novel orphan G-protein-coupled receptors.”. Genomics 56 (1): 12–21. DOI:10.1006/geno.1998.5655. PMID 10036181.
Hirai H, Tanaka K, Yoshie O, et al. (2001). „Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.”. J. Exp. Med. 193 (2): 255–61. DOI:10.1084/jem.193.2.255. PMC 2193345. PMID 11208866.
Hirai H, Tanaka K, Takano S, et al. (2002). „Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2.”. J. Immunol. 168 (3): 981–5. PMID 11801628.
Iwasaki M, Nagata K, Takano S, et al. (2002). „Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis.”. J. Invest. Dermatol. 119 (3): 609–16. DOI:10.1046/j.1523-1747.2002.01862.x. PMID 12230502.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Böhm E, Sturm GJ, Weiglhofer I, et al. (2004). „11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.”. J. Biol. Chem. 279 (9): 7663–70. DOI:10.1074/jbc.M310270200. PMID 14668348.
Huang JL, Gao PS, Mathias RA, et al. (2005). „Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability.”. Hum. Mol. Genet. 13 (21): 2691–7. DOI:10.1093/hmg/ddh279. PMID 15345705.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Venet F, Lepape A, Debard AL, et al. (2004). „The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock.”. Clin. Immunol. 113 (3): 278–84. DOI:10.1016/j.clim.2004.07.005. PMID 15507393.
Gazi L, Gyles S, Rose J, et al. (2005). „Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.”. Prostaglandins Other Lipid Mediat. 75 (1-4): 153–67. DOI:10.1016/j.prostaglandins.2004.11.003. PMID 15789622.
Hata AN, Lybrand TP, Breyer RM (2005). „Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.”. J. Biol. Chem. 280 (37): 32442–51. DOI:10.1074/jbc.M502563200. PMID 16030019.
Sandig H, Andrew D, Barnes AA, et al. (2006). „9alpha,11beta-PGF2 and its stereoisomer PGF2alpha are novel agonists of the chemoattractant receptor, CRTH2.”. FEBS Lett. 580 (2): 373–9. DOI:10.1016/j.febslet.2005.11.052. PMID 16378605.
Schratl P, Royer JF, Kostenis E, et al. (2007). „The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking.”. J. Immunol. 179 (7): 4792–9. PMID 17878378.

Vanjske veze

„Prostanoid Receptors: DP₂”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH GPR44+protein,+human