TFRC

edit

Transferinski receptor (p90, CD71)

PDB prikaz baziran na 1cx8.

Dostupne strukture

1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N

Identifikatori

Simboli

TFRC; CD71; T9; TFR; TFR1; TR; TRFR; p90

Vanjski ID

OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC Gene

Ontologija gena
Molekularna funkcija	• aktivnost transferinskog receptora • aktivnost peptidaze
Celularna komponenta	• ekstracelularni region • endozom • ćelijska membrana • integralno sa ćelijskom membranom • kaveola • membrana
Biološki proces	• proteoliza • ćelijska homeostaza jona gvožđa • interakcija virusa i domaćina

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 3:
195.75 - 195.81 Mb

Chr 16:
32.61 - 32.63 Mb

PubMed pretraga

[1]

[2]

Transferinski receptor 1 (TfR1, Klaster diferencijacije 71, CD71) je protein koji je kod ljudi kodiran TFRC genom.^[1]^[2] TfR1 je neohodan za prenos gvožđa vezanog za transferin u ćelije.^[3]^[4]

Interakcije

TFRC formira interakcije sa GABARAP^[5] i HFE.^[6]^[7]

Reference

↑ Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). „Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin”. Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. DOI:10.1073/pnas.78.7.4515. PMC 319822. PMID 6270680.
↑ Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). „Regional localization of the human transferrin receptor gene to 3q26.2----qter”. Am. J. Hum. Genet. 37 (6): 1112–6. PMC 1684729. PMID 3002171.
↑ Aisen P (November 2004). „Transferrin receptor 1”. Int. J. Biochem. Cell Biol. 36 (11): 2137–43. DOI:10.1016/j.biocel.2004.02.007. PMID 15313461.
↑ Moos T (November 2002). „Brain iron homeostasis”. Danish Medical Bulletin 49 (4): 279–301. PMID 12553165.
↑ Green F, O'Hare T, Blackwell A, Enns CA (May 2002). „Association of human transferrin receptor with GABARAP”. FEBS Lett. 518 (1–3): 101–6. DOI:10.1016/S0014-5793(02)02655-8. PMID 11997026.
↑ Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). „The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding”. Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. DOI:10.1073/pnas.95.4.1472. PMC 19050. PMID 9465039.
↑ West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). „Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE”. J. Biol. Chem. 275 (49): 38135–8. DOI:10.1074/jbc.C000664200. PMID 11027676.

Povezano

PDB Galerija

1cx8: Kristalna struktura ektodomena ljudskog transferinskog receptora

1de4: Hemohromatozni protein HFE u kompleksu sa transferinskim receptorom

1suv: Struktura kompleksa ljudskog transferinskog receptora i transferina

2nsu: Kristalna struktura ektodomena ljudskog transferinskog receptora

p r u Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

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