FZD9

Uvojiti receptor 9
Identifikatori
Simboli	FZD9; CD349; FZD3
Vanjski ID	OMIM: 601766 MGI: 1313278 HomoloGene: 2619 IUPHAR: FZD9 GeneCards: FZD9 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora • receptorsko vezivanje • proteinsko vezivanje • Wnt proteinsko vezivanje • vezivanje PDZ domena
Celularna komponenta	• citoplazma • ćelijska površina • integralno sa membranom • sinaptosom • membrana neuronske projekcije
Biološki proces	• pozitivna regulacija proteinske fosforilacije • razvoj vaskulature • morfogeneza odlivnog trakta • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
	podaci
Ortolozi

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Uvojiti-9 je protein koji je kod ljudi kodiran FZD9 genom.^[1]^[2]^[3] FZD9 se takođe označava kao CD349 (klaster diferencijacije 349).

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD4 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD9 gen je lociran unutar regiona na hromozomu 7 čije brisanje proizvodi Vilijamsonov sindrom. Heterozigotno brisanje FZD9 gena može da doprinese fenotipu Vilijamsovog sindroma. FZD9 je predominantno izražen u mozgu, testisima, očima, skeletalnim mišićima, i bubrezima.^[3]

Reference

↑ Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (May 1997). „A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23”. Hum Mol Genet 6 (3): 465–72. DOI:10.1093/hmg/6.3.465. PMID 9147651.
↑ Wang YK, Sporle R, Paperna T, Schughart K, Francke U (May 1999). „Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome”. Genomics 57 (2): 235–48. DOI:10.1006/geno.1999.5773. PMID 10198163.
↑ ^3,0 ^3,1 „Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)”.

Literatura

Datta DV (1977). „Viral hepatitis (Chandigarh study)”. The Journal of the Association of Physicians of India 25 (5): 325–30. PMID 914765.
Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Tanaka S, Akiyoshi T, Mori M, et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. DOI:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
Karasawa T, Yokokura H, Kitajewski J, Lombroso PJ (2002). „Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling”. J. Biol. Chem. 277 (40): 37479–86. DOI:10.1074/jbc.M205658200. PMID 12138115.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Winn RA, Marek L, Han SY, et al. (2005). „Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation”. J. Biol. Chem. 280 (20): 19625–34. DOI:10.1074/jbc.M409392200. PMID 15705594.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Winn RA, Van Scoyk M, Hammond M, et al. (2006). „Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma”. J. Biol. Chem. 281 (37): 26943–50. DOI:10.1074/jbc.M604145200. PMID 16835228.

Povezano

Uvojiti receptori

Vanjske veze

„Frizzled Receptors: FZD₉”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-03-19.
MeSH FZD9+protein,+human

[pmid9147651-1] Wang YK, Samos CH, Peoples R, Perez-Jurado LA, Nusse R, Francke U (May 1997). „A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23”. Hum Mol Genet 6 (3): 465–72. DOI:10.1093/hmg/6.3.465. PMID 9147651.

[pmid10198163-2] Wang YK, Sporle R, Paperna T, Schughart K, Francke U (May 1999). „Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome”. Genomics 57 (2): 235–48. DOI:10.1006/geno.1999.5773. PMID 10198163.

[entrez-3] 3,0 ^3,1 „Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)”.

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FZD9

Reference

Literatura

Povezano

Vanjske veze

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