Receptor ukusa tip 2 član 16 je protein koji je kod ljudi kodiran TAS2R16 genom .[ 1] [ 2]
Varijante ovog gena su povezane sa povećanim rizikom od alkoholne zavisnosti .[ 3]
TAS2R16 gen je lociran na dugačkoj (q) ruci hromozoma 7 u poziciji 31.1 - 31.3, od baznog para 122.228.764 do baznog para 122.229.639.
Reference
Literatura
Kinnamon SC (2000). „A plethora of taste receptors.”. Neuron 25 (3): 507–10. DOI :10.1016/S0896-6273(00)81054-5 . PMID 10774719 .
Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1–4. DOI :10.1074/jbc.R100054200 . PMID 11696554 .
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI :10.1016/S0959-4388(02)00345-8 . PMID 12139982 .
Adler E, Hoon MA, Mueller KL, et al. (2000). „A novel family of mammalian taste receptors.”. Cell 100 (6): 693–702. DOI :10.1016/S0092-8674(00)80705-9 . PMID 10761934 .
Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors.”. Cell 100 (6): 703–11. DOI :10.1016/S0092-8674(00)80706-0 . PMID 10761935 .
Firestein S (2000). „The good taste of genomics.”. Nature 404 (6778): 552–3. DOI :10.1038/35007167 . PMID 10766221 .
Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse.”. Nature 404 (6778): 601–4. DOI :10.1038/35007072 . PMID 10766242 .
Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.”. Nat. Genet. 32 (3): 397–401. DOI :10.1038/ng1014 . PMID 12379855 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” . Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell 112 (3): 293–301. DOI :10.1016/S0092-8674(03)00071-0 . PMID 12581520 .
Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI :10.1038/nature01782 . PMID 12853948 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” . Genome Res. 14 (10B): 2121–7. DOI :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.” . Mol. Biol. Evol. 22 (3): 432–6. DOI :10.1093/molbev/msi027 . PMID 15496549 .
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.” . Genetics 170 (1): 313–26. DOI :10.1534/genetics.104.037523 . PMC 1449719 . PMID 15744053 .
Mueller KL, Hoon MA, Erlenbach I, et al. (2005). „The receptors and coding logic for bitter taste.”. Nature 434 (7030): 225–9. DOI :10.1038/nature03352 . PMID 15759003 .
Hinrichs AL, Wang JC, Bufe B, et al. (2006). „Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.” . Am. J. Hum. Genet. 78 (1): 103–11. DOI :10.1086/499253 . PMC 1380207 . PMID 16385453 .
Behrens M, Bartelt J, Reichling C, et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression.”. J. Biol. Chem. 281 (29): 20650–9. DOI :10.1074/jbc.M513637200 . PMID 16720576 .
Vanjske veze
Povezano
Klasa A : Rodopsinu slični
Adenozinski (
A1 ,
A2A ,
A2B ,
A3 ) •
P2Y (
1 ,
2 ,
4 ,
5 ,
6 ,
8 ,
9 ,
10 ,
11 ,
12 ,
13 ,
14 )
Drugi
Acetilholin (
M1 ,
M2 ,
M3 ,
M4 ,
M5 ) •
Dopamin (
D1 ,
D2 ,
D3 ,
D4 ,
D5 ) •
Histamin (
H1 ,
H2 ,
H3 ,
H4 ) •
Melatonin (
1A ,
1B ,
1C ) •
TAAR (
1 ,
2 ,
3 ,
5 ,
6 ,
8 ,
9 )
Metaboliti i signalni molekuli
Drugi
Žučna kiselina •
Kanabinoidni (
CB1 ,
CB2 ,
GPR (
18 ,
55 ,
119 )) •
EBI2 •
Estrogen •
Slobodna masna kiselina (
1 ,
2 ,
3 ,
4 ) •
Laktat •
Lizofosfatidna kiselina (
1 ,
2 ,
3 ,
4 ,
5 ,
6 ) •
Lizofosfolipid (
1 ,
2 ,
3 ,
4 ,
5 ,
6 ,
7 ,
8 ) •
Niacin (
1 ,
2 ) •
Oksoglutarat •
PAF •
Sfingozin-1-fosfat (
1 ,
2 ,
3 ,
4 ,
5 ) •
Sukcinat
Peptid
Drugi
Anafilatoksin (
C3a ,
C5a ) •
Angiotenzin (
1 ,
2 ) •
Apelin •
Bombezin (
BRS3 ,
GRPR ,
NMBR ) •
Bradikinin (
B1 ,
B2 ) •
Hemokin •
Holecistokinin (
A ,
B ) •
Endotelin (
A ,
B ) •
Formil peptid (
1 ,
2 ,
3 ) •
FSH •
Galanin (
1 ,
2 ,
3 ) •
GHB receptor •
Gonadotropin-oslobađajući hormon (
1 ,
2 ) •
Grelin •
Kispeptin •
Luteinizirajući hormon/horiogonadotropin •
MAS (
1 ,
1L ,
D ,
E ,
F ,
G ,
X1 ,
X2 ,
X3 ,
X4 ) •
Melanokortin (
1 ,
2 ,
3 ,
4 ,
5 ) •
MCHR (
1 ,
2 ) •
Motilin •
Opioidni (
δ ,
κ ,
μ ,
Nociceptin &
ζ , ali ne
σ ) •
Oreksin (
1 ,
2 ) •
Oksitocin •
Prokineticin (
1 ,
2 ) •
Prolaktin-oslobađajući peptid •
Relaksin (
1 ,
2 ,
3 ,
4 ) •
Somatostatin (
1 ,
2 ,
3 ,
4 ,
5 ) •
Tahikinin (
1 ,
2 ,
3 ) •
Tirotropin •
Tirotropin-oslobađajući hormon •
Urotenzin-II •
Vazopresin (
1A ,
1B ,
2 )
Razno
GPR (
1 ,
3 ,
4 ,
6 ,
12 ,
15 ,
17 ,
18 ,
19 ,
20 ,
21 ,
22 ,
23 ,
25 ,
26 ,
27 ,
31 ,
32 ,
33 ,
34 ,
35 ,
37 ,
39 ,
42 ,
44 ,
45 ,
50 ,
52 ,
55 ,
61 ,
62 ,
63 ,
65 ,
68 ,
75 ,
77 ,
78 ,
81 ,
82 ,
83 ,
84 ,
85 ,
87 ,
88 ,
92 ,
101 ,
103 ,
109A ,
109B ,
119 ,
120 ,
132 ,
135 ,
137B ,
139 ,
141 ,
142 ,
146 ,
148 ,
149 ,
150 ,
151 ,
152 ,
153 ,
160 ,
161 ,
162 ,
171 ,
173 ,
174 ,
176 ,
177 ,
182 ,
183 )
Drugi
Adrenomedulin •
Mirisni •
Opsin (
3 ,
4 ,
5 ,
1LW ,
1MW ,
1SW ,
RGR ,
RRH ) •
Proteazom-aktivirani (
1 ,
2 ,
3 ,
4 ) •
SREB (
1 ,
2 ,
3 )
Klasa B : Sekretinu slični
GPR (
56 ,
64 ,
97 ,
98 ,
110 ,
111 ,
112 ,
113 ,
114 ,
115 ,
116 ,
123 ,
124 ,
125 ,
126 ,
128 ,
133 ,
143 ,
144 ,
155 ,
157 )
Drugi
Moždano specifični angiogenezni inhibitor (
1 ,
2 ,
3 ) •
Cadherin (
1 ,
2 ,
3 ) •
Kalcitonin •
CALCRL •
CD97 •
Kortikotropin-oslobađajući hormon (
1 ,
2 ) •
EMR (
1 ,
2 ,
3 ) •
Glukagon (
GR ,
GIPR ,
GLP1R ,
GLP2R ) •
Hormon rasta oslobađajući hormon •
PACAPR1 •
GPR •
Latrofilin (
1 ,
2 ,
3 ,
ELTD1 ) •
Metuselah-slični proteini •
Paratiroidni hormon (
1 ,
2 ) •
Sekretin •
Vazoaktivni intestinalni peptid (
1 ,
2 )
Klasa C : Metabotropni glutamat / feromon
TAS1R (
1 ,
2 ,
3 ) •
TAS2R (
1 ,
3 ,
4 ,
5 ,
8 ,
9 ,
10 ,
12 ,
13 ,
14 ,
16 ,
19 ,
20 ,
30 ,
31 ,
38 ,
39 ,
40 ,
41 ,
42 ,
43 ,
45 ,
46 ,
50 )
Drugi
Kalcijum-detektujući receptor •
GABA B (
1 ,
2 ) •
Glutamatni receptor (
Metabotropni glutamat (
1 ,
2 ,
3 ,
4 ,
5 ,
6 ,
7 ,
8 )) •
GPRC6A •
GPR (
156 ,
158 ,
179 ) •
RAIG (
1 ,
2 ,
3 ,
4 )
Klasa F:Frizzled / Zaglađeni
B trdu : peptidi (nrpl /grfl /cytl /horl ), receptori (lgic , enzr , gprc , igsr , intg , nrpr /grfr /cytr ), itra (adap , gbpr , mapk ), calc , lipd , signalni putevi (hedp , wntp , tgfp +mapp , notp , jakp , fsap , hipp , tlrp )