Melanokortin receptor 3 je protein koji je kod ljudi kodiran MC3Rgenom.[1][2]
MC3 je G-protein spregnuti receptor za melanocit-stimulišući hormon i adrenokortikotropski hormon koji je izražen u tkivima izvan adrenalnog korteksa i melanocita. MC3R gen je lociran u istom regionu kao i locus za benignu neonatalnu epilepsiju. Miševi koji su deficitarni u ovom genu imaju povišenu masu masnog tkiva uprkos umanjenog unosa hrane, što sugestira ulogu ovog genskog produkta u regulaciji energijske homeostaze.[2]
Magenis RE, Smith L, Nadeau JH, et al. (1994). „Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.”. Mamm. Genome5 (8): 503–8. DOI:10.1007/BF00369320. PMID7949735.
Konda Y, Gantz I, DelValle J, et al. (1994). „Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor.”. J. Biol. Chem.269 (18): 13162–6. PMID8175743.
Gantz I, Tashiro T, Barcroft C, et al. (1994). „Localization of the genes encoding the melanocortin-2 (adrenocorticotropic hormone) and melanocortin-3 receptors to chromosomes 18p11.2 and 20q13.2-q13.3 by fluorescence in situ hybridization.”. Genomics18 (1): 166–7. DOI:10.1006/geno.1993.1448. PMID8276410.
Yang YK, Ollmann MM, Wilson BD, et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol.11 (3): 274–80. DOI:10.1210/me.11.3.274. PMID9058374.
Tota MR, Smith TS, Mao C, et al. (1999). „Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.”. Biochemistry38 (3): 897–904. DOI:10.1021/bi9815602. PMID9893984.
McNulty JC, Thompson DA, Bolin KA, et al. (2002). „High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.”. Biochemistry40 (51): 15520–7. DOI:10.1021/bi0117192. PMID11747427.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature414 (6866): 865–71. DOI:10.1038/414865a. PMID11780052.
Lee YS, Poh LK, Loke KY (2002). „A novel melanocortin 3 receptor gene (MC3R) mutation associated with severe obesity.”. J. Clin. Endocrinol. Metab.87 (3): 1423–6. DOI:10.1210/jc.87.3.1423. PMID11889220.
Rached M, Buronfosse A, Begeot M, Penhoat A (2004). „Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity.”. Biochim. Biophys. Acta1689 (3): 229–34. DOI:10.1016/j.bbadis.2004.03.009. PMID15276649.
Tao YX, Segaloff DL (2004). „Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.”. J. Clin. Endocrinol. Metab.89 (8): 3936–42. DOI:10.1210/jc.2004-0367. PMID15292330.
Lapinsh M, Veiksina S, Uhlén S, et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol.67 (1): 50–9. DOI:10.1124/mol.104.002857. PMID15470082.
Mandrika I, Petrovska R, Wikberg J (2005). „Melanocortin receptors form constitutive homo- and heterodimers.”. Biochem. Biophys. Res. Commun.326 (2): 349–54. DOI:10.1016/j.bbrc.2004.11.036. PMID15582585.
de Krom M, de Rijke CE, Hendriks J, et al. (2006). „Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients.”. Psychiatr. Genet.15 (4): 237. DOI:10.1097/00041444-200512000-00003. PMID16314751.
Chen M, Aprahamian CJ, Celik A, et al. (2006). „Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction.”. Biochemistry45 (4): 1128–37. DOI:10.1021/bi0521792. PMID16430209.
„Melanocortin Receptors: MC3”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-02-06.
