PROFILPELAJAR.COM

Bombezinu-sličan receptor 3‎
Identifikatori
Simboli	BRS3;
Vanjski ID	OMIM: 300107 MGI: 1100501 HomoloGene: 1307 IUPHAR: BB3 GeneCards: BRS3 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost bombezinskog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa membranom;
Biološki proces	• glukozni metabolički proces; • kontrakcija glatkih mišića; • prenos signala; • signalni put G-protein spregnutog receptora; • response na nutrijente; • regulacija krvnog pritiska; • način ishrane odraslih osoba;
Pregled RNK izražavanja
	podaci
Ortolozi

edit

Bombezinu-sličan receptor 3 (BRS-3, BB₃)^[1] je protein koji je kod ljudi kodiran BRS3 genom.^[2]^[3]

Funkcija

Kod sisara su bombezinu-slični peptidi široko rasprostranjeni u centralnom nervnom sistemu, kao i u gastrointenstinalnom traktu, gde oni modulišu kontrakcije glatkih mišića, eksokrine i endokrine procese, metabolizam, i ponašanje. Oni deluju putem vezivanja za G protein-spregnute receptore na ćelijskoj površni. Bombezinu-slični peptidni receptori su gastrin-oslobađajući peptidni receptor, neuromedinski B receptor, i bombezinu-sličan receptor-3.^[3]^[4]

BB₃ je G protein-spregnuti receptor,^[5] koji ima nizak afinitet za prirodne bombezinu-srodne peptide. Njegov endogeni ligand visokog afiniteta nije poznat, te je ovaj receptor klasifikovan kao orfanski receptor.^[2]^[6]^[7]

Literatura

↑ „Bombesin Receptors: BB₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
↑ ^2,0 ^2,1 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. ^{[mrtav link]}
↑ ^3,0 ^3,1 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). „Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse”. Brain Res. 762 (1-2): 165–72. DOI:10.1016/S0006-8993(97)00380-6. PMID 9262170.
↑ „Entrez Gene: BRS3 bombesin-like receptor 3”.
↑ Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. Arhivirano iz originala na datum 2007-12-27. Pristupljeno 2014-05-08.
↑ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). „Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.”. J. Biol. Chem. 272 (41): 26062–26071. DOI:10.1074/jbc.272.41.26062. PMID 9325344.
↑ Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). „International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.”. Pharmacol. Rev. 60 (1): 1–42. DOI:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

Dodatna literatura

Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). „Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.”. FEBS Lett. 340 (3): 260–4. DOI:10.1016/0014-5793(94)80150-9. PMID 8131855.
Fathi Z, Corjay MH, Shapira H, et al. (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
Kane MA, Toi-Scott M, Johnson GL, et al. (1996). „Bombesin-like peptide receptors in human bronchial epithelial cells.”. Peptides 17 (1): 111–8. DOI:10.1016/0196-9781(95)02088-8. PMID 8822519.
Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). „Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.”. Nature 390 (6656): 165–9. DOI:10.1038/36568. PMID 9367152.
Ryan RR, Weber HC, Hou W, et al. (1998). „Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.”. J. Biol. Chem. 273 (22): 13613–24. DOI:10.1074/jbc.273.22.13613. PMID 9593699.
Liu J, Lao ZJ, Zhang J, et al. (2002). „Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).”. Biochemistry 41 (28): 8954–60. DOI:10.1021/bi0202777. PMID 12102638.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). „The DNA sequence of the human X chromosome.”. Nature 434 (7031): 325–37. DOI:10.1038/nature03440. PMC 2665286. PMID 15772651.
Hou X, Wei L, Harada A, Tatamoto K (2007). „Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.”. Lung Cancer 54 (2): 143–8. DOI:10.1016/j.lungcan.2006.08.005. PMID 16979789.
Tan YR, Qin XQ, Xiang Y, et al. (2007). „PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.”. Biochem. J. 405 (1): 131–7. DOI:10.1042/BJ20061754. PMC 1925247. PMID 17355223.

Vanjske veze

„Bombesin Receptors: BB₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.
MeSH bombesin+receptor+subtype+3

[IUPHAR-DB-1] „Bombesin Receptors: BB₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[pmid8383682-2] 2,0 ^2,1 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. ^{[mrtav link]}

[pmid9262170-3] 3,0 ^3,1 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). „Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse”. Brain Res. 762 (1-2): 165–72. DOI:10.1016/S0006-8993(97)00380-6. PMID 9262170.

[entrez-4] „Entrez Gene: BRS3 bombesin-like receptor 3”.

[autogenerated1-5] Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (1993). „BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells”. J. Biol. Chem. 268 (8): 5979–84. PMID 8383682. Arhivirano iz originala na datum 2007-12-27. Pristupljeno 2014-05-08.

[pmid9325344-6] Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH and Jensen RT. (1997). „Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors.”. J. Biol. Chem. 272 (41): 26062–26071. DOI:10.1074/jbc.272.41.26062. PMID 9325344.

[pmid18055507-7] Jensen RT, Battey JF, Spindel ER and Benya RV. (2007). „International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states.”. Pharmacol. Rev. 60 (1): 1–42. DOI:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

[1]

[2]

[3]

[4]

[5]

[6]

[7]