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G protein-spregnuti receptor 132
Identifikatori
Simboli	GPR132; G2A; MGC99642
Vanjski ID	OMIM: 606167 MGI: 1890220 HomoloGene: 8350 IUPHAR: GPR132 GeneCards: GPR132 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora; • receptorska aktivnost;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• G1/S prenos mitotičkog ćelijskog ciklusa; • prenos signal; • signalni put G-protein spregnutog receptora;
Pregled RNK izražavanja
	podaci
Ortolozi

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GPR132, G protein-spregnuti receptor 132, je protein koji je kod čoveka kodiran GPR132 genom.^[1]^[2]

GPR132 je receptor visokog afiniteta za lizofosfatidilholin (LPC), jednu od fosfolipidnih komponenti oksidovanih lipoproteina niske gustine. Ovaj protein može da reaguje na promenu LPC nivoa na mestima zapaljenja i da ograniči ekspanziju ćelija ćelija koje infiltriraju tkivo. Sličan protein kod miša učestvuje u progresiji ćelijskog cilusa.^[2]

Povezano

Proton-indicirajući G protein-spregnuti receptori

Literatura

↑ Le LQ, Kabarowski JH, Wong S, Nguyen K, Gambhir SS, Witte ON (Jun 2002). „Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene”. Cancer Cell 1 (4): 381–91. DOI:10.1016/S1535-6108(02)00058-2. PMID 12086852.
↑ ^2,0 ^2,1 „Entrez Gene: GPR132 G protein-coupled receptor 132”. PMID 29933.

Dodatna literatura

Weng Z, Fluckiger AC, Nisitani S, et al. (1998). „A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.”. Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334–9. DOI:10.1073/pnas.95.21.12334. PMC 22832. PMID 9770487.
Kabarowski JH, Zhu K, Le LQ, et al. (2001). „Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.”. Science 293 (5530): 702–5. DOI:10.1126/science.1061781. PMID 11474113.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rikitake Y, Hirata K, Yamashita T, et al. (2002). „Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.”. Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049–53. DOI:10.1161/01.ATV.0000040598.18570.54. PMID 12482833.
Lin P, Ye RD (2003). „The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.”. J. Biol. Chem. 278 (16): 14379–86. DOI:10.1074/jbc.M209101200. PMID 12586833.
Lum H, Qiao J, Walter RJ, et al. (2003). „Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.”. Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. DOI:10.1152/ajpheart.00359.2003. PMID 12805023.
Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). „G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.”. J. Biol. Chem. 279 (41): 42484–91. DOI:10.1074/jbc.M406561200. PMID 15280385.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Witte ON, Kabarowski JH, Xu Y, et al. (2005). „Retraction.”. Science 307 (5707): 206. DOI:10.1126/science.307.5707.206b. PMID 15653487.
Radu CG, Nijagal A, McLaughlin J, et al. (2005). „Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.”. Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. DOI:10.1073/pnas.0409415102. PMC 545089. PMID 15665078.
Obinata H, Hattori T, Nakane S, et al. (2006). „Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.”. J. Biol. Chem. 280 (49): 40676–83. DOI:10.1074/jbc.M507787200. PMID 16236715.
Frasch SC, Zemski-Berry K, Murphy RC, et al. (2007). „Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.”. J. Immunol. 178 (10): 6540–8. PMID 17475884.