S1PR5

Sfingozin 1-fosfatni receptor 5
Identifikatori
Simboli	S1PR5; EDG8; Edg-8; S1P5; SPPR-1; SPPR-2
Vanjski ID	OMIM: 605146 MGI: 2150641 HomoloGene: 11031 IUPHAR: S1P5 GeneCards: S1PR5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora • aktivnost faktora guanil-nukleotidne razmene • vezivanje masne kiseline
Celularna komponenta	• ćelijska membrana • integralno sa ćelijskom membranom
Biološki proces	• metabolički proces energetske rezerve • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
	podaci
Ortolozi

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Sfingozin 1-fosfat receptor 5 (S1PR5) je ljudski gen koji kodira G protein spregnuti receptor za koji se vezuje lipidni signalni molekul sfingozin 1-fosfat (S1P).^[1]

Reference

↑ „Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5”.

Literatura

Im DS, Heise CE, Ancellin N, et al. (2000). „Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.”. J. Biol. Chem. 275 (19): 14281–6. DOI:10.1074/jbc.275.19.14281. PMID 10799507.
Malek RL, Toman RE, Edsall LC, et al. (2001). „Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.”. J. Biol. Chem. 276 (8): 5692–9. DOI:10.1074/jbc.M003964200. PMID 11069896.
Hla T (April 2001). Sphingosine 1-phosphate receptors.. 64. pp. 135–142. PMID 11331101.
Im DS, Clemens J, Macdonald TL, Lynch KR (2001). „Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.”. Biochemistry 40 (46): 14053–60. DOI:10.1021/bi011606i. PMID 11705398.
Takeda S, Kadowaki S, Haga T, et al. (2002). „Identification of G protein-coupled receptor genes from the human genome sequence.”. FEBS Lett. 520 (1-3): 97–101. DOI:10.1016/S0014-5793(02)02775-8. PMID 12044878.
Niedernberg A, Scherer CR, Busch AE, Kostenis E (2002). „Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists.”. Biochem. Pharmacol. 64 (8): 1243–50. DOI:10.1016/S0006-2952(02)01289-3. PMID 12234605.
Kothapalli R, Kusmartseva I, Loughran TP (2003). „Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.”. Biochim. Biophys. Acta 1579 (2-3): 117–23. DOI:10.1016/S0167-4781(02)00529-8. PMID 12427546.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vogler R, Sauer B, Kim DS, et al. (2003). „Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.”. J. Invest. Dermatol. 120 (4): 693–700. DOI:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). „The DNA sequence and biology of human chromosome 19.”. Nature 428 (6982): 529–35. DOI:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ulfig N, Briese M (2005). „Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers.”. Acta Histochem. 106 (5): 373–8. DOI:10.1016/j.acthis.2004.08.002. PMID 15530552.
Rual JF, Venkatesan K, Hao T, et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res. 12 (2): 117–26. DOI:10.1093/dnares/12.2.117. PMID 16303743.

Povezano

Lizofosfolipidni receptor

Vanjske veze

„Lysophospholipid Receptors: S₁P₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-12-08.
MeSH Lysophospholipid+receptors

[entrez-1] „Entrez Gene: S1PR5 Sphingosine-1-phosphate receptor 5”.

[1]

S1PR5

Reference

Literatura

Povezano

Vanjske veze

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