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Receptor ukusa tip 2 član 5
Identifikatori
Simboli	TAS2R5; T2R5
Vanjski ID	OMIM: 605062 HomoloGene: 49580 IUPHAR: GeneCards: TAS2R5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa;
Celularna komponenta	• integralno sa membranom;
Biološki proces	• signalni put G-protein spregnutog receptora; • hemosensorno ponašanje; • detekcija hemijskog stimulusa koji učestvuje u senzornoj percepciji ukusa;
Ortolozi

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Receptor ukusa tip 2 član 5 je protein koji je kod ljudi kodiran TAS2R5 genom..^[1]

Ovaj protein je član familije of mogućih receptora ukusa. On pripada grupi G protein spregnutih receptora i specifično je izražen u ćelijama ukusa jezika i epitela nepci. On deluje kao receptor gorkog ukusa. Ovaj receptor ukusa ne sadrži introne. Njegov gen se nalazi na hromozomu 7.^[1]

Reference

↑ ^1,0 ^1,1 „Entrez Gene: TAS2R5 taste receptor, type 2, member 5”.

Literatura

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Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). „The receptors and cells for mammalian taste.”. Nature 444 (7117): 288–94. DOI:10.1038/nature05401. PMID 17108952.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). „Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.”. Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. DOI:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Adler E, Hoon MA, Mueller KL, et al. (2000). „A novel family of mammalian taste receptors.”. Cell 100 (6): 693–702. DOI:10.1016/S0092-8674(00)80705-9. PMID 10761934.
Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). „T2Rs function as bitter taste receptors.”. Cell 100 (6): 703–11. DOI:10.1016/S0092-8674(00)80706-0. PMID 10761935.
Firestein S (2000). „The good taste of genomics.”. Nature 404 (6778): 552–3. DOI:10.1038/35007167. PMID 10766221.
Matsunami H, Montmayeur JP, Buck LB (2000). „A family of candidate taste receptors in human and mouse.”. Nature 404 (6778): 601–4. DOI:10.1038/35007072. PMID 10766242.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). „The DNA sequence of human chromosome 7.”. Nature 424 (6945): 157–64. DOI:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

Povezano

Receptor ukusa

[entrez-1] 1,0 ^1,1 „Entrez Gene: TAS2R5 taste receptor, type 2, member 5”.

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