Prostaciklinski receptor

Prostaglandinski I2 (prostaciklinski) receptor (IP1)
Identifikatori
Simboli	PTGIR; MGC102830; PRIPR
Vanjski ID	OMIM: 600022 MGI: 99535 HomoloGene: 7496 IUPHAR: IP1 GeneCards: PTGIR Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost • receptorska aktivnost • tromboksanska receptorska aktivnost
Celularna komponenta	• integralno sa ćelijskom membranom • membrana • integralno sa membranom
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora • G-protein signalizacija, spregnuta sa cikličnim nukleotidom kao sekundarnim glasnikom • ćelija-ćelija signalizacija
Pregled RNK izražavanja
	podaci
Ortolozi

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Prostaciklinski receptor (ili prostaglandinski I₂ receptor, IP₁) je receptor za prostaciklin.

On je član familije G-protein spregnutih receptora. Prostaciklin, glavni proizvod ciklooksigenaze u makrovaskularnom endotelu, uzrokuje potentnu vazodilataciju i inhibiciju agregacije trombocita putem vezivanja za ovaj receptor.^[1]

Transdukcija

Prilikom vezivanja za molekul prostaciklina, receptor konformaciju i aktivira G_s, koji aktivira cAMP i povećava aktivnost proteinske kinaze A (PKA).

Reference

↑ „Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)”.

Literatura

Coleman RA, Smith WL, Narumiya S (1994). „International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.”. Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.
Rauvala H, Peng HB (1997). „HB-GAM (heparin-binding growth-associated molecule) and heparin-type glycans in the development and plasticity of neuron-target contacts.”. Prog. Neurobiol. 52 (2): 127–44. DOI:10.1016/S0301-0082(97)00007-5. PMID 9185236.
Smyth EM, FitzGerald GA (2003). „Human prostacyclin receptor.”. Vitam. Horm. 65: 149–65. DOI:10.1016/S0083-6729(02)65063-0. PMID 12481546.
Boie Y, Rushmore TH, Darmon-Goodwin A, et al. (1994). „Cloning and expression of a cDNA for the human prostanoid IP receptor.”. J. Biol. Chem. 269 (16): 12173–8. PMID 7512962.
Katsuyama M, Sugimoto Y, Namba T, et al. (1994). „Cloning and expression of a cDNA for the human prostacyclin receptor.”. FEBS Lett. 344 (1): 74–8. DOI:10.1016/0014-5793(94)00355-6. PMID 7514139.
Ogawa Y, Tanaka I, Inoue M, et al. (1995). „Structural organization and chromosomal assignment of the human prostacyclin receptor gene.”. Genomics 27 (1): 142–8. DOI:10.1006/geno.1995.1016. PMID 7665161.
Duncan AM, Anderson LL, Funk CD, et al. (1995). „Chromosomal localization of the human prostanoid receptor gene family.”. Genomics 25 (3): 740–2. DOI:10.1016/0888-7543(95)80022-E. PMID 7759114.
Nakagawa O, Tanaka I, Usui T, et al. (1994). „Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.”. Circulation 90 (4): 1643–7. PMID 7923647.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery.”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.
Sasaki Y, Takahashi T, Tanaka I, et al. (1997). „Expression of prostacyclin receptor in human megakaryocytes.”. Blood 90 (3): 1039–46. PMID 9242534.
Fisch A, Tobusch K, Veit K, et al. (1997). „Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.”. Circulation 96 (3): 756–60. PMID 9264479.
Smyth EM, Li WH, FitzGerald GA (1998). „Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.”. J. Biol. Chem. 273 (36): 23258–66. DOI:10.1074/jbc.273.36.23258. PMID 9722557.
Kömhoff M, Lesener B, Nakao K, et al. (1999). „Localization of the prostacyclin receptor in human kidney.”. Kidney Int. 54 (6): 1899–908. DOI:10.1046/j.1523-1755.1998.00213.x. PMID 9853255.
Hayes JS, Lawler OA, Walsh MT, Kinsella BT (1999). „The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.”. J. Biol. Chem. 274 (34): 23707–18. DOI:10.1074/jbc.274.34.23707. PMID 10446129.
Smyth EM, Austin SC, Reilly MP, FitzGerald GA (2000). „Internalization and sequestration of the human prostacyclin receptor.”. J. Biol. Chem. 275 (41): 32037–45. DOI:10.1074/jbc.M003873200. PMID 10889200.
Lawler OA, Miggin SM, Kinsella BT (2001). „Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.”. J. Biol. Chem. 276 (36): 33596–607. DOI:10.1074/jbc.M104434200. PMID 11443126.
Zhang Z, Austin SC, Smyth EM (2001). „Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction.”. Mol. Pharmacol. 60 (3): 480–7. PMID 11502878.
Fortier I, Patry C, Lora M, et al. (2001). „Immunohistochemical localization of the prostacyclin receptor (IP) human bone.”. Prostaglandins Leukot. Essent. Fatty Acids 65 (2): 79–83. DOI:10.1054/plef.2001.0292. PMID 11545623.

Povezano

Eikozanoidni receptor

Vanjske veze

„Prostanoid Receptors: IP₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] „Entrez Gene: PTGIR prostaglandin I2 (prostacyclin) receptor (IP)”.

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