TAS2R38

Receptor ukusa tip 2 član 38
Identifikatori
Simboli	TAS2R38; PTC; T2R38; T2R61
Vanjski ID	OMIM: 607751 MGI: 2681306 HomoloGene: 47976 IUPHAR: GeneCards: TAS2R38 Gene
Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa
Celularna komponenta	• integralno sa membranom
Biološki proces	• signalni put G-protein spregnutog receptora
Ortolozi

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Receptor ukusa tip 2 član 38 je protein koji je kod ljudi kodiran TAS2R38 genom. TAS2R38 je receptor gorkog ukusa. Različiti genotipi ovog receptora utiču na sposobnost prepoznavanja ukusa 6-n-propiltiouracila (PROP)^[1] i feniltiokarbamida (PTC).^[2]^[3] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the only taste receptors shown to have this function.^[4]

Prenos signala

Kao i kod svih TAS2R proteina, TAS2R38 koristi G-protein gustducin kao svoj primarni metod prenosa signala. Jedinice α i βγ su esencijalne za prenos signala ukusa.^[5]

Reference

↑ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research 28 (11): 1629–1637. DOI:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448.
↑ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses 29 (8): 697–702. DOI:10.1093/chemse/bjh074. PMID 15466815.
↑ Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics 67 (4): 275–280. DOI:10.1111/j.1399-0004.2004.00361.x. PMID 15733260.
↑ Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition 27: 389–414. DOI:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812.
↑ Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.

Literatura

Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste”. Curr. Opin. Neurobiol. 12 (4): 366–71. DOI:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Anne-Spence M, Falk CT, Neiswanger K, et al. (1984). „Estimating the recombination frequency for the PTC-Kell linkage”. Hum. Genet. 67 (2): 183–6. DOI:10.1007/BF00272997. PMID 6745938.
Bufe B, Hofmann T, Krautwurst D, et al. (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat. Genet. 32 (3): 397–401. DOI:10.1038/ng1014. PMID 12379855.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways”. Cell 112 (3): 293–301. DOI:10.1016/S0092-8674(03)00071-0. PMID 12581520.
Conte C, Ebeling M, Marcuz A, et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family”. Cytogenet. Genome Res. 98 (1): 45–53. DOI:10.1159/000068546. PMID 12584440.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). „Human Chromosome 7: DNA Sequence and Biology”. Science 300 (5620): 767–72. DOI:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Pronin AN, Tang H, Connor J, Keung W (2005). „Identification of ligands for two human bitter T2R receptors”. Chem. Senses 29 (7): 583–93. DOI:10.1093/chemse/bjh064. PMID 15337684.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes”. Mol. Biol. Evol. 22 (3): 432–6. DOI:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates”. Genetics 170 (1): 313–26. DOI:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

Vanjske veze

Povezano

Receptor ukusa

[p15547448-1] Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM (2004). „Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake”. Alcoholism, clinical and experimental research 28 (11): 1629–1637. DOI:10.1097/01.ALC.0000145789.55183.D4. PMC 1397913. PMID 15547448.

[p15466815-2] Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A (2004). „Bitter Taste Study in a Sardinian Genetic Isolate Supports the Association of Phenylthiocarbamide Sensitivity to the TAS2R38 Bitter Receptor Gene”. Chemical Senses 29 (8): 697–702. DOI:10.1093/chemse/bjh074. PMID 15466815.

[p15733260-3] Kim UK, Drayna D (2004). „Genetics of individual differences in bitter taste perception: Lessons from the PTC gene”. Clinical Genetics 67 (4): 275–280. DOI:10.1111/j.1399-0004.2004.00361.x. PMID 15733260.

[p17444812-4] Bachmanov AA, Beauchamp GK (2007). „Taste Receptor Genes”. Annual Review of Nutrition 27: 389–414. DOI:10.1146/annurev.nutr.26.061505.111329. PMC 2721271. PMID 17444812.

[5] Margolskee RF (2001). „Molecular Mechanisms of Bitter and Sweet Taste Transduction”. Journal of Biological Chemistry 277 (1): 1–4. DOI:10.1074/jbc.R100054200. PMID 11696554.

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