G protein spregnuti receptor, familija C, grupa 5, član A je protein koji je kod ljudi kodiran GPRC5Agenom.[1][2]
Ovaj protein pripada familiji tipa 3 G protein spregnutih receptora, koja ima karakteristični 7-transmembranski domen. On potencijalno učestvuje u interakciji između retinoidne kiseline i G protein signalnih puteva. Retinoinska kiselina ima kritičnu ulogu u razvoju, ćelijskom rastu, i diferencijaciji. Ovaj gen potencijalno učestvuje u embrionskom razvoju i diferencijaciji epitelnih ćelija.[2]
Reference
↑Cheng Y, Lotan R (Feb 1999). „Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor”. J Biol Chem273 (52): 35008–15. DOI:10.1074/jbc.273.52.35008. PMID9857033.
Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1997). „Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells”. Cell. Mol. Biol. (Noisy-le-grand)42 (5): 797–804. PMID8832110.
Bräuner-Osborne H, Krogsgaard-Larsen P (2000). „Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain”. Genomics65 (2): 121–8. DOI:10.1006/geno.2000.6164. PMID10783259.
Robbins MJ, Michalovich D, Hill J i dr.. (2001). „Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)”. Genomics67 (1): 8–18. DOI:10.1006/geno.2000.6226. PMID10945465.
Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet.36 (1): 40–5. DOI:10.1038/ng1285. PMID14702039.
Tao Q, Cheng Y, Clifford J, Lotan R (2004). „Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid”. Genomics83 (2): 270–80. DOI:10.1016/S0888-7543(03)00237-4. PMID14706456.
Wu Q, Ding W, Mirza A i dr.. (2005). „Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target”. J. Biol. Chem.280 (13): 12935–43. DOI:10.1074/jbc.M409901200. PMID15659406.
Zhang Y, Wolf-Yadlin A, Ross PL i dr.. (2005). „Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules”. Mol. Cell Proteomics4 (9): 1240–50. DOI:10.1074/mcp.M500089-MCP200. PMID15951569.
Hirano M, Zang L, Oka T i dr.. (2006). „Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression”. Biochem. Biophys. Res. Commun.351 (1): 185–91. DOI:10.1016/j.bbrc.2006.10.016. PMID17055459.
„GPRC5 Receptors: RAIG1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-02-03.
