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Proteazom-aktivirani receptor 4
Identifikatori
Simboli	F2RL3; PAR4
Vanjski ID	OMIM: 602779 MGI: 1298207 HomoloGene: 36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • receptorska aktivnost; • aktivnost trombinskog receptora;
Celularna komponenta	• membrana plazme; • integralno sa membranom plazme;
Biološki proces	• prenos signala; • G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom; • koagulacija krvi; • respons na ranjavanje;
Pregled RNK izražavanja
	podaci
Ortolozi

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Proteazom-aktivirani receptor 4 (PAR4), ili Receptoru koagulacionog faktora II (trombina) sličan 3, je protein kodiran F2RL3 genom kod ljudi.^[1]

F2RL3 je član velike familije G-protein spregnutih receptora koji interaguju sa guanozin-nukleotid-vezujućim proteinima. PAR4 je takođe član familije proteazom aktiviranih receptora. On je aktiviran trombinom i tripsinom. Do aktivacije dolazi proteolitičkim odsecanjem njegovog ekstracelularnog amino terminusa. Novo-formirani amino terminus dejstvuje kao vezani ligand i aktivira receptor.^[1]

Povezano

Proteazom-aktivirani receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3”.

Literatura

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„Protease-Activated Receptors: PAR4”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-04-02.