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Hipokretinski (oreksinski) receptor 1
Identifikatori
Simboli	HCRTR1; OX1R
Vanjski ID	OMIM: 602392 MGI: 2385650 HomoloGene: 37492 IUPHAR: OX1 GeneCards: HCRTR1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost neuropeptidnog receptora; • aktivnost oreksinskog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • membrana;
Biološki proces	• prenos signala; • neuropeptidni signalni put; • sinapsna transmisija; • ishrana;
Pregled RNK izražavanja
	podaci
Ortolozi

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Oreksinski receptor tip 1 (OX1R, OX₁, ili hipokretinski receptor tip 1), je protein koji je kod ljudi kodiran HCRTR1 genom.^[1]

Funkcija

OX₁ je G-protein spregnuti receptor koji je izražen u hipotalamusu i učestvuje u regulaciji ishrane. OX₁ selektivno vezuje neuropeptid oreksin-A. On je 64% identičan sa OX₂.^[1]

Ligandi

Agonisti

Oreksin-A

Antagonisti

Almoreksant - neselektivni OX_1/2 antagonist
SB-334,867 - selektivni OX₁ antagonist
SB-408,124 - selektivni OX₁ antagonist
SB-649,868 - neselektivni OX_1/2 antagonist

Povezano

Oreksinski receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: HCRTR1 hypocretin (orexin) receptor 1”.

Literatura

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Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). „To eat or to sleep? Orexin in the regulation of feeding and wakefulness.”. Annu. Rev. Neurosci. 24: 429–58. DOI:10.1146/annurev.neuro.24.1.429. PMID 11283317.
Hungs M, Mignot E (2001). „Hypocretin/orexin, sleep and narcolepsy.”. Bioessays 23 (5): 397–408. DOI:10.1002/bies.1058. PMID 11340621.
de Lecea L, Kilduff TS, Peyron C, et al. (1998). „The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.”. Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322–7. DOI:10.1073/pnas.95.1.322. PMC 18213. PMID 9419374.
Sakurai T, Amemiya A, Ishii M, et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.” (PDF). Cell 92 (4): 573–85. DOI:10.1016/S0092-8674(00)80949-6. PMID 9491897. Arhivirano iz originala na datum 2011-07-11. Pristupljeno 2014-05-08.
Sakurai T, Amemiya A, Ishii M, et al. (1998). „Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.”. Cell 92 (5): 697. DOI:10.1016/S0092-8674(02)09256-5. PMID 9527442.
Peyron C, Faraco J, Rogers W, et al. (2000). „A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.”. Nat. Med. 6 (9): 991–7. DOI:10.1038/79690. PMID 10973318.
Blanco M, López M, GarcIa-Caballero T, et al. (2001). „Cellular localization of orexin receptors in human pituitary.”. J. Clin. Endocrinol. Metab. 86 (7): 3444–7. DOI:10.1210/jc.86.7.3444. PMID 11443222.
Olafsdóttir BR, Rye DB, Scammell TE, et al. (2002). „Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.”. Neurology 57 (10): 1896–9. PMID 11723285.
Wieland HA, Söll RM, Doods HN, et al. (2002). „The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor.”. Eur. J. Biochem. 269 (4): 1128–35. DOI:10.1046/j.0014-2956.2001.02739.x. PMID 11856342.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hilairet S, Bouaboula M, Carrière D, et al. (2003). „Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716.”. J. Biol. Chem. 278 (26): 23731–7. DOI:10.1074/jbc.M212369200. PMID 12690115.
Karteris E, Chen J, Randeva HS (2004). „Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.”. J. Clin. Endocrinol. Metab. 89 (4): 1957–62. DOI:10.1210/jc.2003-031778. PMID 15070969.
Holmqvist T, Johansson L, Ostman M, et al. (2005). „OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.”. J. Biol. Chem. 280 (8): 6570–9. DOI:10.1074/jbc.M407397200. PMID 15611118.
Spinazzi R, Rucinski M, Neri G, et al. (2005). „Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.”. J. Clin. Endocrinol. Metab. 90 (6): 3544–9. DOI:10.1210/jc.2004-2385. PMID 15797953.
Meerabux J, Iwayama Y, Sakurai T, et al. (2005). „Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects.”. Biol. Psychiatry 58 (5): 401–7. DOI:10.1016/j.biopsych.2005.04.015. PMID 15978554.
Ziolkowska A, Spinazzi R, Albertin G, et al. (2006). „Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor.”. J. Steroid Biochem. Mol. Biol. 96 (5): 423–9. DOI:10.1016/j.jsbmb.2005.05.003. PMID 16157481.

Vanjske veze

„Orexin Receptors: OX₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-02-06.