Ibodutant

Ibodutant
(IUPAC) ime
Nα-[(1- {[(6-metil-1-benzotien-2-il)karbonil]amino}ciklopentil)karbonil]-N[1-(tetrahidro-2H-piran-4-ilmetil)piperidin-4-il]metilD-fenilalaninamid
Klinički podaci
Identifikatori
ATC kod nije dodeljen
PubChem[1][2] 11527495
Hemijski podaci
Formula C37H48N4O4S 
Mol. masa 644,866 g/mol
SMILES eMolekuli & PubHem
Sinonimi 6-metil-N-[1-[[(2R)-1-[[1-(oksan-4-ilmetil)piperidin-4- il]metilamino]-1-okso-3-fenilpropan-2-il]karbamoil]ciklopentil]-1-benzotiofen-2-karboksamid
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Ibodutant je kandidat leka za upalnu bolest creva, koji je razvila Menarini grupa.

Metod dejstva

Ibodutant selektivno blokira tahikininski receptor NK2. Blokada je praktično kompletna na nanomolarnim koncentracijama.[3][4]

Povezano

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ H. Spreitzer (2008-05-26). „Neue Wirkstoffe - Ibodutant” (German). Österreichische Apothekerzeitung (11/2008): 541. 
  4. ↑ S. Giuliani, M. Altamura, C. A. Maggi. „Ibodutant. Tachykinin NK2 receptor antagonist, Treatment of irritable bowel syndrome.”. Drugs of the Future 33 (2): 111–115. 

Vanjske veze

Portal Medicina
Portal Hemija

Šablon:Neuropeptidni ligandi

Read other articles:

Putatan

Distrik Putatan Lokasi kota dan distrik Putatan Geografi StatusDistrik Asal namaN/A Negara Malaysia Negara bagian Sabah DistrikDistrik Putatan KeluasanN/A Putatan merupakan sebuah distrik yang terletak di Bagian Pantai Barat di negara bagian Sabah. Distrik ini terletak di antara distrik Penampang, Papar, dan Kota Kinabalu. Sejak 1 Maret 2007, Putatan telah dipisahkan dari pemerintahan distrik Penampang untuk menjadi sebuah distrik penuh di Sabah.[1] Pada tahun berakhir 2007...

 

Giovanni Battista Ayroli

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

 

Madeline Brewer

American actress Madeline BrewerBrewer in 2017BornMadeline Kathryn Brewer (1992-05-01) May 1, 1992 (age 31)Pitman, New Jersey, U.S.Alma materAmerican Musical and Dramatic AcademyOccupationActressYears active2013–present Madeline Kathryn Brewer[1] (born May 1, 1992) is an American actress, known for recurring roles in the Netflix series Orange Is the New Black (2013) and Hemlock Grove (2014–2015). She stars as Janine Lindo in the Hulu series The Handmaid's Tale (2017...

Kepolisian Daerah Nusa Tenggara Barat

Polisi Daerah Nusa Tenggara BaratLambang Polda Nusa Tenggara BaratSingkatanPolda NTBMottoMemelihara keamanan dan ketertiban, menegakkan hukum, memberikan perlindungan, pengayoman dan pelayanan kepada masyarakatStruktur yurisdiksiWilayah hukumNusa Tenggara Barat, IndonesiaPeta Wilayah Yuridiksi Polda NTBKategoriLembaga sipil lokalStruktur operasionalPengawasKepolisian Republik IndonesiaMarkas besarJl. Langko No. 77 Taman Sari, Ampenan, Kota MataramPejabat eksekutifInspektur Jenderal Polisi Drs...

 

Werner Krauss (academic)

German academic (1900–1976) Werner KraussBorn(1900-06-07)7 June 1900Stuttgart, Württemberg, GermanyDied26 August 1976Berlin, East GermanyOccupation(s)University professorAnti-Nazi activistPolitical partyKPD (1945–1946)SED (1947–1976)SpouseDoris SchumacherParent(s)Rudolf Krauss [de]Ottilie Schüle Werner Krauss (7 June 1900 – 28 August 1976) was a German university professor (Romance studies).[1] During the 1940s he became a political activist and resistance fight...

 

Somaglia

SomagliaKomuneComune di SomagliaNegaraItaliaWilayahLombardyProvinsiProvinsi Lodi (LO)FrazioniSan Martino PizzolanoLuas • Total20,9 km2 (81 sq mi)Ketinggian57 m (187 ft)Populasi (Dec. 2004) • Total3.384 • Kepadatan16/km2 (42/sq mi)DemonimSomagliesiZona waktuUTC+1 (CET) • Musim panas (DST)UTC+2 (CEST)Kode pos26867Kode area telepon0377Situs webSitus web resmi Somaglia adalah komune yang terletak di distrik Provins...

Seychelles International Airport

AirportSeychelles International AirportAéroport de la Pointe LarueIATA: SEZICAO: FSIASummaryAirport typePublic / MilitaryOperatorSeychelles Civil Aviation AuthorityServesVictoria, SeychellesHub forAir SeychellesElevation AMSL12 ft / 4 mCoordinates04°40′28″S 55°31′19″E / 4.67444°S 55.52194°E / -4.67444; 55.52194WebsiteOfficial websiteMapSEZLocation of airport in SeychellesRunways Direction Length Surface m ft 13/31 2,997 9,833 Concrete Stati...

 

Louis-François Richer Laflèche

Pour les articles homonymes, voir Laflèche et Richer. Louis-François Laflèche Louis-François Laflèche (1818-1898) Biographie Naissance 4 septembre 1818 à Sainte-Anne-de-la-PéradeSainte-Anne-de-la-Pérade Ordination sacerdotale 7 janvier 1844 à la cathédrale de Québec Décès 14 juillet 1898 à Trois-Rivières (à 79 ans)Trois-Rivières Évêque de l'Église catholique Ordination épiscopale 25 février 1867 à Trois-Rivières Dernier titre ou fonction Évêque de Trois-Rivièr...

 

Liglet

Ligletcomune Liglet – Veduta LocalizzazioneStato Francia Regione Nuova Aquitania Dipartimento Vienne ArrondissementMontmorillon CantoneMontmorillon TerritorioCoordinate46°31′N 1°05′E / 46.516667°N 1.083333°E46.516667; 1.083333 (Liglet)Coordinate: 46°31′N 1°05′E / 46.516667°N 1.083333°E46.516667; 1.083333 (Liglet) Superficie51,29 km² Abitanti296[1] (2009) Densità5,77 ab./km² Altre informazioniCod. postale86290 ...

Kabupaten Sarolangun

Kabupaten SarolangunKabupatenTranskripsi bahasa daerah • Abjad JawiسارولاڠونGerbang Selamat Datang di Sarolangun LambangMotto: Sepucuk adat, serumpun psekoPetaKabupaten SarolangunPetaTampilkan peta SumatraKabupaten SarolangunKabupaten Sarolangun (Indonesia)Tampilkan peta IndonesiaKoordinat: 2°18′S 102°39′E / 2.3°S 102.65°E / -2.3; 102.65Negara IndonesiaProvinsiJambiTanggal berdiri12 Oktober 1999Dasar hukumUU 54/1999Ibu kotaSa...

 

Sang Pencerah

2010 Indonesian filmSang PencerahPromotional film posterDirected byHanung BramantyoScreenplay byHanung BramantyoProduced byRaam PunjabiStarringLukman SardiZaskia Adya MeccaSlamet RahardjoIhsan TaroreGiring GaneshaCinematographyFaozan RizalEdited byWawan I. WibowoMusic byTya Subiakto SatrioProductioncompanyMVP PicturesRelease date September 8, 2010 (2010-09-08) (Indonesia) Running time112 minutesCountryIndonesiaLanguagesIndonesian JavaneseBudgetRp. 12 billion (US$ 1.3 milli...

 

Bengaline

1880s woman's paletot in black bengaline Bengaline is a rayon-and-cotton material which became fashionable for women and children to wear in the 1880s and 1890s. It offered the impression of genuine silk but was made with lesser amounts of silk than cotton. Lizzie Borden stated at her December 1892 inquest that she was wearing a dress made of bengaline silk on the morning she was accused of murdering her father and stepmother.[citation needed] The fabric went out of fashion when compl...

Ian Stewart, Baron Stewartby

British Conservative Party politician and numismatist The Right HonourableThe Lord StewartbyPC Kt RD FSA FRSE FBAMinister of State for Northern IrelandIn office25 July 1988 – 25 July 1989Prime MinisterMargaret ThatcherPreceded byJohn StanleySucceeded byJohn CopeMinister of State for the Armed ForcesIn office13 June 1987 – 25 July 1988Prime MinisterMargaret ThatcherPreceded byJohn StanleySucceeded byArchie HamiltonEconomic Secretary to the TreasuryIn o...

 

Nick Robinson (journalist)

British political journalist (born 1963) Nick RobinsonRobinson outside St Stephen's Club, London in May 2010BornNicholas Anthony Robinson (1963-10-05) 5 October 1963 (age 60)Macclesfield, Cheshire, England, United KingdomEducationCheadle Hulme SchoolAlma materUniversity College, OxfordOccupationJournalistYears active1986–presentEmployerBBCKnown forPresenter of The Today Programme (2015–present)Notable credit(s)PanoramaBBC NewsITNTitlePolitical Editor of BBC News (2005�...

 

Escudo de la provincia de Santa Cruz (Argentina)

Escudo de la provincia de Santa Cruz InformaciónProvincia  Santa CruzFecha de adopción 25 de septiembre de 1959 (64 años)DescripciónBlasón Escudo de forma ovalada.Tenante Corona de laurel, atada con una cinta celeste y blanca en la punta.[editar datos en Wikidata] El escudo de la provincia de Santa Cruz es uno de los escudos provinciales más modernos de Argentina ya que fue oficializado el 25 de septiembre de 1955. Características Se inspira en cierta configuración...

2022–23 Central Connecticut Blue Devils men's basketball team

American college basketball season 2022–23 Central Connecticut Blue Devils men's basketballConferenceNortheast ConferenceRecord10–22 (7–9 NEC)Head coachPatrick Sellers (2nd season)Assistant coaches Ben Wood Lenny Jefferson Ryan Olander Home arenaWilliam H. Detrick GymnasiumSeasons← 2021–222023–24 → 2022–23 Northeast Conference men's basketball standings vte Conf Overall Team W   L   PCT W   L   PCT Merrimack*† 12 – 4 ...

 

Montagne

Vous lisez un « bon article » labellisé en 2018. Pour les articles homonymes, voir Montagne (homonymie). Vue d'une partie de l'Himalaya, avec l'Everest (près du centre), et du plateau tibétain depuis la Station spatiale internationale. Vue d'alpinistes (coin inférieur droit) évoluant entre une rimaye et une crevasse sur l'Alpamayo, au Pérou. Une montagne (Écouter) est une forme topographique de relief positif, à la surface de planètes telluriques, et faisant partie d'un ...

 

David Schumacher

David SchumacherKebangsaan JermanLahir23 Oktober 2001 (umur 22)Terkait denganRalf Schumacher (ayah)Michael Schumacher (paman)Mick Schumacher (sepupu)Karier ADAC Formula 4Musim debut2018Tim saat iniUS Racing-CHRSNomor mobil27Start20Menang0Pole0Lap tercepat0Hasil terbaik9th di 2018Ajang sebelumnya20182017-18Euroformula Open ChampionshipFormula 4 UAE ChampionshipGelar juara2018ADAC Formula 4 Rookie Champion David Schumacher (lahir 23 Oktober 2001) adalah seorang pembalap mobil asal Jerman. ...

Felidhoo (Vaavu Atoll)

Inhabited island in Felidhu Atoll, MaldivesFelidhoo ފެލިދޫInhabited islandFelidhooLocation in MaldivesCoordinates: 03°28′18″N 73°32′50″E / 3.47167°N 73.54722°E / 3.47167; 73.54722CountryMaldivesGeographic atollFelidhu AtollAdministrative atollVaavu AtollDistance to Malé77.92 km (48.42 mi)Population (2014)[1] • Total506 (including foreigners)Time zoneUTC+05:00 (MST) Felidhoo (Dhivehi: ފެލިދޫ) is one of the inha...

 

Subbotnik

Days of organized volunteering in the Soviet Union and modern Russia For other uses, see Subbotnik (disambiguation). For the Judaism-identifying communities, see Subbotniks. Vladimir Lenin at the All-Russia Subbotnik in the Kremlin grounds, Moscow, May 1, 1920 Subbotnik and voskresnik (from Russian: суббо́та, IPA: [sʊˈbotə] for Saturday and воскресе́нье, IPA: [vəskrʲɪˈsʲenʲjɪ] for Sunday) were days of volunteer unpaid work on weekends after th...