P2RY14

Purinski receptor P2Y, G-protein spregnuti, 14
Identifikatori
Simboli	P2RY14; GPR105; KIAA0001; P2Y14
Vanjski ID	OMIM: 610116 MGI: 2155705 HomoloGene: 15769 IUPHAR: P2Y14 GeneCards: P2RY14 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • aktivnost purinskog nukleotidnog receptora, G-protein spregnutog • aktivnost UDP-aktiviranog nukleotidnog receptora
Celularna komponenta	• membrana • integralno sa membranom
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
	podaci
Ortolozi

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P2Y purinoceptor 14 je protein koji je kod ljudi kodiran P2RY14 genom.^[1]

Proizvod P2RY14 gena pripada familiji G-protein spregnutih receptora. Postoji nekoliko tipova receptora sa različitom farmakološkom selektivnošću za razne adenozinske i uridinske nukleotide. Ovaj receptor je P2Y purinski receptor za UDP-glukozu i druge UDP-šećere spregnute sa G-proteinima. Smatra se da on učestvuje u dejstvu imunskog sistema putem regulacije matičnih ćelija, kao i u neuroimunskim funkcijama. Dve transkriptne varijante koje kodiraju isti protein su poznate.^[1]

Povezano

P2Y receptor

Reference

↑ ^1,0 ^1,1 „Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14”.

Literatura

Gerard C, Gerard NP (1994). „C5A anaphylatoxin and its seven transmembrane-segment receptor.”. Annu. Rev. Immunol. 12: 775–808. DOI:10.1146/annurev.iy.12.040194.004015. PMID 8011297.
Müller CE (2003). „P2-pyrimidinergic receptors and their ligands.”. Curr. Pharm. Des. 8 (26): 2353–69. DOI:10.2174/1381612023392937. PMID 12369950.
Abbracchio MP, Boeynaems JM, Barnard EA, et al. (2003). „Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.”. Trends Pharmacol. Sci. 24 (2): 52–5. DOI:10.1016/S0165-6147(02)00038-X. PMID 12559763.
von Kügelgen I (2006). „Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.”. Pharmacol. Ther. 110 (3): 415–32. DOI:10.1016/j.pharmthera.2005.08.014. PMID 16257449.
Brunschweiger A, Müller CE (2006). „P2 receptors activated by uracil nucleotides--an update.”. Curr. Med. Chem. 13 (3): 289–312. DOI:10.2174/092986706775476052. PMID 16475938.
Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.”. DNA Res. 1 (1): 27–35. DOI:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).”. DNA Res. 1 (1): 47–56. DOI:10.1093/dnares/1.1.47. PMID 7584028.
Charlton ME, Williams AS, Fogliano M, et al. (1997). „The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge.”. Brain Res. 764 (1-2): 141–8. DOI:10.1016/S0006-8993(97)00438-1. PMID 9295203.
Joensuu T, Hämäläinen R, Lehesjoki AE, et al. (2000). „A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q.”. Genomics 63 (3): 409–16. DOI:10.1006/geno.1999.6096. PMID 10704288.
Chambers JK, Macdonald LE, Sarau HM, et al. (2000). „A G protein-coupled receptor for UDP-glucose.”. J. Biol. Chem. 275 (15): 10767–71. DOI:10.1074/jbc.275.15.10767. PMID 10753868.
Wittenberger T, Schaller HC, Hellebrand S (2001). „An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.”. J. Mol. Biol. 307 (3): 799–813. DOI:10.1006/jmbi.2001.4520. PMID 11273702.
Joensuu T, Hämäläinen R, Yuan B, et al. (2001). „Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.”. Am. J. Hum. Genet. 69 (4): 673–84. DOI:10.1086/323610. PMC 1226054. PMID 11524702.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). „Release of cellular UDP-glucose as a potential extracellular signaling molecule.”. Mol. Pharmacol. 63 (5): 1190–7. DOI:10.1124/mol.63.5.1190. PMID 12695547.
Lee BC, Cheng T, Adams GB, et al. (2003). „P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.”. Genes Dev. 17 (13): 1592–604. DOI:10.1101/gad.1071503. PMC 196132. PMID 12842911.
Skelton L, Cooper M, Murphy M, Platt A (2003). „Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose.”. J. Immunol. 171 (4): 1941–9. PMID 12902497.
Moore DJ, Murdock PR, Watson JM, et al. (2004). „GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.”. Brain Res. Mol. Brain Res. 118 (1-2): 10–23. DOI:10.1016/S0169-328X(03)00330-9. PMID 14559350.

Vanjske veze

„P2Y Receptors: P2Y₁₄”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] 1,0 ^1,1 „Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14”.

[1]

P2RY14

Povezano

Reference

Literatura

Vanjske veze

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