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Neuropeptidni B/W receptor 2
Identifikatori
Simboli	NPBWR2; GPR8
Vanjski ID	OMIM: 600731 HomoloGene: 48336 IUPHAR: NPBW2 GeneCards: NPBWR2 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost opioidnog receptora; • proteinsko vezivanje;
Celularna komponenta	• membrana; • integralno sa membranom;
Biološki proces	• prenost signala; • signalni put G-protein spregnutog receptora; • neuropeptidni signalni put; • sinaptička transmisija;
Pregled RNK izražavanja
	podaci
Ortolozi

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Neuropeptidni B/W receptor 2 (NPBW2) je humani protein kodiran NPBWR2 genom.^[1]

Ovaj protein je integralni membranski protein i G protein-spregnuti receptor. Njegova sekvenca je slična GPR7 receptoru. On je strukturno sličan opioidnim i somatostatinskim receptorima. Ovaj protein vezuje neuropeptide B i W. Ovaj gen ne sadrži introne. Prvenstveno je izražen u frontalnom korteksu mozga.^[1]

Povezano

Neuropeptidni B/W receptor

Literatura

↑ ^1,0 ^1,1 „Entrez Gene: NPBWR2 neuropeptides B/W receptor 2”.

Dodatna literatura

O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). „The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.”. Genomics 28 (1): 84–91. DOI:10.1006/geno.1995.1109. PMID 7590751.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). „The DNA sequence and comparative analysis of human chromosome 20.”. Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
Shimomura Y, Harada M, Goto M, et al. (2002). „Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 277 (39): 35826–32. DOI:10.1074/jbc.M205337200. PMID 12130646.
Brezillon S, Lannoy V, Franssen JD, et al. (2003). „Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.”. J. Biol. Chem. 278 (2): 776–83. DOI:10.1074/jbc.M206396200. PMID 12401809.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanaka H, Yoshida T, Miyamoto N, et al. (2003). „Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.”. Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251–6. DOI:10.1073/pnas.0837789100. PMC 156358. PMID 12719537.
Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). „G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.”. J. Clin. Endocrinol. Metab. 90 (6): 3466–71. DOI:10.1210/jc.2004-2132. PMID 15797961.

Vanjske veze

„Neuropeptide B/W Receptors: NPBW2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

[entrez-1] 1,0 ^1,1 „Entrez Gene: NPBWR2 neuropeptides B/W receptor 2”.

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