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G protein spregnuti receptor 124
Identifikatori
Simboli	GPR124; TEM5
Vanjski ID	OMIM: 606823 MGI: 1925810 HomoloGene: 13112 IUPHAR: GPR124 GeneCards: GPR124 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom;
Biološki proces	• ćelijska adhezija; • signalni put G protein spregnutog receptora; • neuropeptidni signalni put; • razvoj centralnog nervnog sistema; • endotelna ćelijska migracija; • regulacija angiogeneze; • regulacija hemotakse;
Pregled RNK izražavanja
	podaci
Ortolozi

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G protein spregnuti receptor 124 je protein koji je kod ljudi kodiran GPR124 genom.^[1]^[2]^[3]

Interakcije

GPR124 formira interakcije sa interact sa DLG1.^[4]

Reference

↑ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). „Cell surface tumor endothelial markers are conserved in mice and humans”. Cancer Res 61 (18): 6649–55. PMID 11559528.
↑ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (February 2003). „There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini”. Biochem Biophys Res Commun 301 (3): 725–34. DOI:10.1016/S0006-291X(03)00026-3. PMID 12565841.
↑ „Entrez Gene: GPR124 G protein-coupled receptor 124”.
↑ Yamamoto, Yasunori; Irie Kenji, Asada Masanori, Mino Akihisa, Mandai Kenji, Takai Yoshimi (May 2004). „Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein”. Oncogene (England) 23 (22): 3889–97. DOI:10.1038/sj.onc.1207495. ISSN 0950-9232. PMID 15021905.

Literatura

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). „Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”. DNA Res. 9 (3): 99–106. DOI:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). „Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”. DNA Res. 7 (2): 143–50. DOI:10.1093/dnares/7.2.143. PMID 10819331.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Yamamoto Y, Irie K, Asada M, et al. (2004). „Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.”. Oncogene 23 (22): 3889–97. DOI:10.1038/sj.onc.1207495. PMID 15021905.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.”. Genomics 84 (1): 23–33. DOI:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Vallon M, Essler M (2006). „Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.”. J. Biol. Chem. 281 (45): 34179–88. DOI:10.1074/jbc.M605291200. PMID 16982628.