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Apelinski receptor
Identifikatori
Simboli	APLNR; FLJ90771; MGC45246; AGTRL1; HG11; APJR; APJ; FLJ96609
Vanjski ID	OMIM: 600052 MGI: 1346086 HomoloGene: 3784 IUPHAR: APJ GeneCards: APLNR Gene
Ontologija gena
Molekularna funkcija	• aktivnost purinskog nukleotidnog receptora, G-protein spregnutog; • aktivnost bradikininskog receptora; • aktivnost angiotenzinskog tip II receptora; • receptorska aktivnost; • aktivnost C-C hemokinskog receptora; • aktivnost receptora trombocit aktivirajućeg faktora; • aktivnost N-formil peptidnog receptora; • aktivnost G-protein spregnutog receptora;
Celularna komponenta	• integralno sa ćelijskom membranom; • integralno sa membranom; • ćelijska membrana;
Biološki proces	• signalni put G-protein spregnutog receptora; • prenos signala; • hemotaksa;
Ortolozi

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Apelinski receptor (takođe poznat APJ receptor) je G protein-spregnuti receptor^[1] koji vezuje apelin.^[2]^[3]^[4]

Reference

↑ O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T (1993). „A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11”. Gene 136 (1-2): 355–60. DOI:10.1016/0378-1119(93)90495-O. PMID 8294032.
↑ Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M (1998). „Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor”. Biochem. Biophys. Res. Commun. 251 (2): 471–6. DOI:10.1006/bbrc.1998.9489. PMID 9792798.
↑ Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, Osmond DH, George SR, O'Dowd BF (2000). „Characterization of apelin, the ligand for the APJ receptor”. J. Neurochem. 74 (1): 34–41. DOI:10.1046/j.1471-4159.2000.0740034.x. PMID 10617103.
↑ Szokodi I, Tavi P, Földes G, Voutilainen-Myllylä S, Ilves M, Tokola H, Pikkarainen S, Piuhola J, Rysä J, Tóth M, Ruskoaho H (2002). „Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility”. Circ. Res. 91 (5): 434–40. DOI:10.1161/01.RES.0000033522.37861.69. PMID 12215493.

Literatura

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Kälin RE, Kretz MP, Meyer AM, et al. (2007). „Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis.”. Dev. Biol. 305 (2): 599–614. DOI:10.1016/j.ydbio.2007.03.004. PMID 17412318.
Zhou N, Zhang X, Fan X, et al. (2003). „The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.”. Virology 317 (1): 84–94. DOI:10.1016/j.virol.2003.08.026. PMID 14675627.
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Zhou N, Fan X, Mukhtar M, et al. (2003). „Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ.”. Virology 307 (1): 22–36. DOI:10.1016/S0042-6822(02)00021-1. PMID 12667811.
Li WW, Niu WQ, Zhang Y, et al. (2009). „Family-based analysis of apelin and AGTRL1 gene polymorphisms with hypertension in Han Chinese.”. J. Hypertens. 27 (6): 1194–201. DOI:10.1097/HJH.0b013e32832a3eb1. PMID 19307984.
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Lee DK, LanÃ§a AJ, Cheng R, et al. (2004). „Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors.”. J. Biol. Chem. 279 (9): 7901–8. DOI:10.1074/jbc.M306377200. PMID 14645236.
Choe H, Martin KA, Farzan M, et al. (1998). „Structural interactions between chemokine receptors, gp120 Env and CD4.”. Semin. Immunol. 10 (3): 249–57. DOI:10.1006/smim.1998.0127. PMID 9653051.
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Kleinz MJ, Skepper JN, Davenport AP (2005). „Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.”. Regul. Pept. 126 (3): 233–40. DOI:10.1016/j.regpep.2004.10.019. PMID 15664671.
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Cobellis L, De Falco M, Mastrogiacomo A, et al. (2007). „Modulation of apelin and APJ receptor in normal and preeclampsia-complicated placentas.”. Histol. Histopathol. 22 (1): 1–8. PMID 17128405.
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Bai B, Tang J, Liu H, et al. (2008). „Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway.”. Acta Biochim. Biophys. Sin. (Shanghai) 40 (4): 311–8. DOI:10.1111/j.1745-7270.2008.00403.x. PMID 18401529.
Ishida J, Hashimoto T, Hashimoto Y, et al. (2004). „Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo.”. J. Biol. Chem. 279 (25): 26274–9. DOI:10.1074/jbc.M404149200. PMID 15087458.

Vanjske veze

„Apelin Receptor: APJ”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2021-08-16.
MeSH Apelin+receptor,+human