FZD3

Uvojiti receptor 3
Identifikatori
Simboli	FZD3; Fz-3
Vanjski ID	OMIM: 606143 MGI: 108476 HomoloGene: 23004 IUPHAR: FZD3 GeneCards: FZD3 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora • receptorsko vezivanje • proteinsko vezivanje • Wnt proteinsko vezivanje • vezivanje PDZ domena
Celularna komponenta	• citoplazma • ćelijska površina • integralno sa membranom • sinaptosom • membrana neuronske projekcije
Biološki proces	• pozitivna regulacija proteinske fosforilacije • razvoj vaskulature • morfogeneza odlivnog trakta • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom
Pregled RNK izražavanja
	podaci
Ortolozi

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Uvojiti-3 je protein koji je kod ljudi kodiran FZD3 genom.^[1]^[2]^[3]

Članovi familije 'uvojitih' proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD3 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. FZD3 transkript je izražen u različitim tkivima. Funkcija ovog proteina nije poznata. Postoje izvesne indikacije da učestvuje u razvoju folikula dlake kod sisara.^[3]

Reference

↑ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). „Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun 271 (1): 8–14. DOI:10.1006/bbrc.2000.2578. PMID 10777673.
↑ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). „Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun 273 (1): 27–34. DOI:10.1006/bbrc.2000.2882. PMID 10873558.
↑ ^3,0 ^3,1 „Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.

Literatura

Katoh M (2002). „GIPC gene family (Review).”. Int. J. Mol. Med. 9 (6): 585–9. PMID 12011974.
Finch PW, He X, Kelley MJ, et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. DOI:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
Wright M, Aikawa M, Szeto W, Papkoff J (1999). „Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.”. Biochem. Biophys. Res. Commun. 263 (2): 384–8. DOI:10.1006/bbrc.1999.1344. PMID 10491302.
Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). „Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.”. J. Invest. Dermatol. 116 (6): 940–6. DOI:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Katsu T, Ujike H, Nakano T, et al. (2004). „The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.”. Neurosci. Lett. 353 (1): 53–6. DOI:10.1016/j.neulet.2003.09.017. PMID 14642436.
Zhang Y, Yu X, Yuan Y, et al. (2005). „Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.”. Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. DOI:10.1002/ajmg.b.30076. PMID 15274031.
Zhang Z, Henzel WJ (2005). „Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819–24. DOI:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Omoto S, Hayashi T, Kitahara K, et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).”. Ophthalmic Genet. 25 (2): 81–90. DOI:10.1080/13816810490514270. PMID 15370539.
Hashimoto R, Suzuki T, Iwata N, et al. (2005). „Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.”. Journal of neural transmission (Vienna, Austria : 1996) 112 (2): 303–7. DOI:10.1007/s00702-004-0264-2. PMID 15657645.

Povezano

Uvojiti receptori

Vanjske veze

„Frizzled Receptors: FZD₃”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-09-03.

[pmid10777673-1] Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). „Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21”. Biochem Biophys Res Commun 271 (1): 8–14. DOI:10.1006/bbrc.2000.2578. PMID 10777673.

[pmid10873558-2] Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). „Identification, gene structure, and expression of human frizzled-3 (FZD3)”. Biochem Biophys Res Commun 273 (1): 27–34. DOI:10.1006/bbrc.2000.2882. PMID 10873558.

[entrez-3] 3,0 ^3,1 „Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)”.

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[3]

FZD3

Reference

Literatura

Povezano

Vanjske veze

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