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Melanokortin 5 receptor
Identifikatori
Simboli	MC5R;
Vanjski ID	OMIM: 600042 MGI: 99420 HomoloGene: 4321 IUPHAR: MC5 GeneCards: MC5R Gene
Ontologija gena
Molekularna funkcija	• rodopsinu-slična receptorska aktivnost; • receptorska aktivnost; • receptorska aktivnost melanokortina;
Celularna komponenta	• integralno sa membranom plazme; • membrana;
Biološki proces	• prenos signala; • G-protein signalizacija, spregnuta sa cikličnim nukleotidnim drugim glasnikom;
Pregled RNK izražavanja
	podaci
Ortolozi

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Melanokortin receptor 5 je protein koji je kod ljudi kodiran MC5R genom.^[1]^[2] On je lociran na hromozomu 18 u ljudskom genomu.^[2] Kad se melanokortin 5 receptor onestposobljen kod transgenetskih miševa, indukuju se poremećaji rada njihovih eksokrinih žlezda, što rezultuje u umanjenoj produkciji lojnih žlezdi.^[3]

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Melanokortin receptor

Literatura

↑ Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). „Molecular cloning of a novel human melanocortin receptor”. Biochem Biophys Res Commun 195 (2): 866–73. DOI:10.1006/bbrc.1993.2125. PMID 8396929.
↑ ^2,0 ^2,1 „Entrez Gene: MC5R melanocortin 5 receptor”.
↑ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). „The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells”. Journal of Investigative Dermatology 115 (4): 614–619. DOI:10.1046/j.1523-1747.2000.00094.x. PMID 10998132. Pristupljeno 2008-01-04.

Dodatna literatura

Fathi Z, Iben LG, Parker EM (1995). „Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.”. Neurochem. Res. 20 (1): 107–13. DOI:10.1007/BF00995160. PMID 7739752.
Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). „Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization.”. Cytogenet. Cell Genet. 68 (1-2): 79–81. DOI:10.1159/000133895. PMID 7956366.
Griffon N, Mignon V, Facchinetti P, et al. (1994). „Molecular cloning and characterization of the rat fifth melanocortin receptor.”. Biochem. Biophys. Res. Commun. 200 (2): 1007–14. DOI:10.1006/bbrc.1994.1550. PMID 8179577.
Gantz I, Shimoto Y, Konda Y, et al. (1994). „Molecular cloning, expression, and characterization of a fifth melanocortin receptor.”. Biochem. Biophys. Res. Commun. 200 (3): 1214–20. DOI:10.1006/bbrc.1994.1580. PMID 8185570.
Chhajlani V (1997). „Distribution of cDNA for melanocortin receptor subtypes in human tissues.”. Biochem. Mol. Biol. Int. 38 (1): 73–80. PMID 8932521.
Yang YK, Ollmann MM, Wilson BD, et al. (1997). „Effects of recombinant agouti-signaling protein on melanocortin action.”. Mol. Endocrinol. 11 (3): 274–80. DOI:10.1210/me.11.3.274. PMID 9058374.
Frändberg PA, Xu X, Chhajlani V (1997). „Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.”. Biochem. Biophys. Res. Commun. 236 (2): 489–92. DOI:10.1006/bbrc.1997.6994. PMID 9240466.
Yang YK, Thompson DA, Dickinson CJ, et al. (1999). „Characterization of Agouti-related protein binding to melanocortin receptors.”. Mol. Endocrinol. 13 (1): 148–55. DOI:10.1210/me.13.1.148. PMID 9892020.
Hatta N, Dixon C, Ray AJ, et al. (2001). „Expression, candidate gene, and population studies of the melanocortin 5 receptor.”. J. Invest. Dermatol. 116 (4): 564–70. DOI:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.
Bednarek MA, MacNeil T, Kalyani RN, et al. (2001). „Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.”. J. Med. Chem. 44 (22): 3665–72. DOI:10.1021/jm010165y. PMID 11606131.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lapinsh M, Veiksina S, Uhlén S, et al. (2005). „Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.”. Mol. Pharmacol. 67 (1): 50–9. DOI:10.1124/mol.104.002857. PMID 15470082.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lohoff FW, Berrettini WH (2006). „Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder.”. Psychiatr. Genet. 15 (4): 255–8. DOI:10.1097/00041444-200512000-00007. PMID 16314755.
Grieco P, Cai M, Han G, et al. (2007). „Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.”. Peptides 28 (6): 1191–6. DOI:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720.
„Melanocortin Receptors: MC₅”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-07-14.

[pmid8396929-1] Chhajlani V, Muceniece R, Wikberg JE (Oct 1993). „Molecular cloning of a novel human melanocortin receptor”. Biochem Biophys Res Commun 195 (2): 866–73. DOI:10.1006/bbrc.1993.2125. PMID 8396929.

[entrez-2] 2,0 ^2,1 „Entrez Gene: MC5R melanocortin 5 receptor”.

[3] Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary (2000). „The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells”. Journal of Investigative Dermatology 115 (4): 614–619. DOI:10.1046/j.1523-1747.2000.00094.x. PMID 10998132. Pristupljeno 2008-01-04.

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Melanokortinski 5 receptor

Povezano

Literatura

Dodatna literatura