D1 i D5 receptori su u znatnoj meri strukturno homologni i mali broj selektivnih liganda je dostupan. Postoje brojni ligandi koji su selektivni za D1/5 u odnosu na druge dopaminske receptore. Nedavni razvoj selektivnog D5 antagonista je omogućio ispitivanje D1-posredovanog odgovora u odsustvu D5 komponente. Selektivni D5 agonisti trenutno nisu dostupni.
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„Dopamine Receptors: D1”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-12-31.