L-745,870

L-745,870
(IUPAC) ime
3-([4-(4-hlorofenil)piperazin-1-il]metil)-1H-pirolo[2,3-b]piridin
Klinički podaci
Identifikatori
CAS broj 158985-00-3
ATC kod nije dodeljen
PubChem[1][2] 5311200
Hemijski podaci
Formula C18H19ClN4 
Mol. masa 326,822 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

L-745,870 je lek koji deluje kao dopaminski antagonist. On je selektivni parcijalni agonist D4 podtipa. L-745,870 ima antipsihotično dejstvo u životinjskim modelima. On nije pokazao taj efekat u kliničkim ispitivanjima.[3][4][5]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). „Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist”. Trends in Pharmacological Sciences 18 (6): 186–8. PMID 9226994. 
  4. ↑ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). „Regulation of working memory by dopamine D4 receptor in rats”. Neuropsychopharmacology 29 (9): 1648–55. DOI:10.1038/sj.npp.1300491. PMID 15138447. 
  5. ↑ Moustgaard A, Hau J, Lind NM (2008). „Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats”. Behavioral and Brain Functions 4: 49. DOI:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334. 

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