PROFILPELAJAR.COM

Hidralazin
(IUPAC) ime
	1-hidrazinilftalazin
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a682246
Identifikatori
CAS broj	86-54-4
ATC kod	C02DB02
PubChem	3637
DrugBank	DB01275
ChemSpider	3511
UNII	26NAK24LS8
KEGG	D08044
ChEBI	CHEBI:5775
ChEMBL	CHEMBL276832
Hemijski podaci
Formula	C8H8N4
Mol. masa	160,176 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12) ; Key: RPTUSVTUFVMDQK-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	26-55%
Metabolizam	Hepatički
Poluvreme eliminacije	2-4 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status
Način primene	Oralno, intravenozno

Hidralazin (apresolin) je direktno delujući relaksant glatkih mišića koji se koristi za tretman hipertenzije. On deluje kao vazodilatator prvenstveno u arterijama i arteriolama. Putem relaksacije vaskularnih glatkih mišića, vazodilatatori umanjuju perifernu otpornost, čime snižavaju krvni pritisak.^[6] Međutim, ovaj lek ima samo kratkotrajno dejstvo na krvni pritisak.

Hidralazin pripada hidrazinoftalazinskoj klasi lekova.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Harvey, Richard A., Pamela A. Harvey, and Mark J. Mycek. Lippincott's Illustrated Reviews: Pharmacology. 2nd ed. Philadelphia: Lipincott, Williams & Wilkins, 2000. 190.
↑ Bourreli, B.; Pinaud, M.; Passuti, N.; Gunst, J. P.; Drouet, J. C.; Remi, J. P. (1988). „Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion”. Canadian Journal of Anaesthesia 35 (3): 242–248. DOI:10.1007/BF03010617. PMID 3383316.

Povezano

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Harvey-6] Harvey, Richard A., Pamela A. Harvey, and Mark J. Mycek. Lippincott's Illustrated Reviews: Pharmacology. 2nd ed. Philadelphia: Lipincott, Williams & Wilkins, 2000. 190.

[Bourreli1988-7] Bourreli, B.; Pinaud, M.; Passuti, N.; Gunst, J. P.; Drouet, J. C.; Remi, J. P. (1988). „Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion”. Canadian Journal of Anaesthesia 35 (3): 242–248. DOI:10.1007/BF03010617. PMID 3383316.

[1]

[2]

[3]

[4]

[5]

[6]

[7]