Fenoksipropazin

Fenoksipropazin
(IUPAC) ime
(1-metil-2-fenoksi-etil)hidrazin
Klinički podaci
Identifikatori
CAS broj 3818-37-9
ATC kod nije dodeljen
PubChem[1][2] 71467
ChemSpider[3] 64548
UNII 8E92V52324
ChEMBL[4] CHEMBL1909286
Hemijski podaci
Formula C9H14N2O 
Mol. masa 166,22 g/mol}
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status ℞ Prescription only
Način primene Oralno

Fenoksipropazin (prodajno ime Drazin) je ireverzibilni i neselektivni inhibitor monoaminoksidaze (MAOI) iz hidrazinske hemijske klase. On je uveden u upotrebu kao antidepresiv 1961, ali je naknadno povućen sa tržišta 1966. zbog moguće pojave hepatotoksičnosti.[5][6][7][8][9]

Povezano

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ↑ LEAHY MR, ROSE JT, PLOWMAN R (April 1963). „A preliminary study of phenoxypropazine in the treatment of depression”. The American Journal of Psychiatry 119: 986–7. PMID 13928824. 
  6. ↑ IMLAH NW (May 1963). „Preliminary report on phenoxypropazine”. The American Journal of Psychiatry 119: 1091–2. PMID 13956423. 
  7. ↑ ROSE JT, LEAHY MR, PLOWMAN R (October 1963). „A comparison of phenoxypropazine and amitriptyline in depression”. The American Journal of Psychiatry 120: 393–5. PMID 14069469. 
  8. ↑ ROSE JT (March 1964). „Phenoxypropazine and chlordiazepoxide in depression”. The American Journal of Psychiatry 120: 899–900. PMID 14129290. 
  9. ↑ MCWHINNEY IR, MORRELL DC (January 1965). „Treatment of mild endogenous depression with a monoamine oxidase inhibitor: a controlled trial in general practice”. The Journal of the College of General Practitioners 9: 95–9. PMC 1878242. PMID 14254271. 

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