5-Karboksamidotriptamin

5-Karboksamidotriptamin
(IUPAC) ime
3-(2-aminoethyl)-1H-indole-5-carboxamide
Klinički podaci
Identifikatori
CAS broj 74885-09-9
ATC kod nije dodeljen
PubChem[1][2] 1809
ChemSpider[3] 1743
ChEMBL[4] CHEMBL18840 DaY
Hemijski podaci
Formula C11H13N3O 
Mol. masa 203.240 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

5-Karboksamidotriptamin (5-CT) je triptaminski derivat koji je blisko srodan sa neurotransmiterom serotoninom.

5-CT deluje kao neselektivni pun agonist visokog afiniteta na 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, i 5-HT7 receptore, kao i na 5-HT2, 5-HT3, 5-HT6 receptore sa nižim afinitetom.[5][6][7] On ima neznatan afinitet za 5-HT1E i 5-HT1F receptore.[8] 5-CT se najjače vezuje za 5-HT1A receptor i nekad se smatralo da je selektivan za njega.[9][10]

Povezano

Literatura

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ↑ Yamada J, Sugimoto Y, Noma T, Yoshikawa T. (1998). „Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.”. Eur J Pharmacol. 359 (1): 81–86. DOI:10.1016/S0014-2999(98)00617-7. PMID 9831297. 
  6. ↑ Wright, CE; Angus, JA (1989). „5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.”. Journal of cardiovascular pharmacology 13 (4): 557–64. PMID 2470992. 
  7. ↑ Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000.). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Pristupljeno 11. 04. 2008. 
  8. ↑ Stanton JA, Middlemiss DN, Beer MS. (1996). „Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.”. Neuropharmacology. 35 (2): 223–229. DOI:10.1016/0028-3908(95)00178-6. PMID 8734492. 
  9. ↑ Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). „5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.”. British journal of pharmacology 128 (1): 158–64. DOI:10.1038/sj.bjp.0702759. PMC 1571602. PMID 10498847. 
  10. ↑ Saxena, PR; Lawang, A (1985). „A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.”. Archives internationales de pharmacodynamie et de therapie 277 (2): 235–52. PMID 2933009.