Desformilflustrabromin

Desformilflustrabromin
(IUPAC) ime
2-[6-bromo-2-(2-metilbut-3-en-2-il)-1H-indol-3-il]-N-metiletanamin
Klinički podaci
Identifikatori
CAS broj 474657-72-2
ATC kod nije dodeljen
PubChem[1][2] 637026
ChemSpider[3] 552693
Hemijski podaci
Formula C16H21BrN2 
Mol. masa 321,254 g/mol
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Desformilflustrabromin (dFBr) je triptaminski derivat koji je bio prvo izolovan kao aktivni metabolit morske mahovine Flustra foliacea.[4]

Bioaktivnost

Utvrđeno je da dFBr deluje kao pozitivni alosterni modulator neuronskog nikotinskog acetilholinskog receptora sa podtipnom specifičnošću za heteromerni receptor i bez uticaja na homomerne podtipove.[5] Jedna nedavno objavljena studija je opisala sintezu u vodi rastvornih soli dFBr i potvrdila da one deluju kao selektivni potencijatori α4β2 nikotinskog acetilholinskog receptora koristeći dvoelektrodni metod.[6] Poznato je da je dFBr citotoksičan na HCT-116 ćelijama ljudskog raka debelog creva.[7]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Peters, Lars; Wright, Anthony D.; Kehraus, Stefan; Gündisch, Daniela; Tilotta, M. C.; König, Gabriele M. (October 2004). „Prenylated indole alkaloids from Flustra foliacea with subtype specific binding on NAChRs”. Planta Med. 70 (10): 883–6. DOI:10.1055/s-2004-832610. PMID 15490312. 
  5. ↑ Sala, Francisco; Mulet, José; Reddy, Krishna P.; Bernal, José Antonio; Wikman, Philip; Valor, Luis Miguel; Peters, Lars; König, Gabriele M. i dr.. (January 2005). „Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite”. Neurosci. Lett. 373 (2): 144–9. DOI:10.1016/j.neulet.2004.10.002. PMID 15567570. 
  6. ↑ Kim, Jin-Sung; Padnya, Anshul; Weltzin, Maegan; Edmonds, Brian W.; Schulte, Marvin K.; Glennon, Richard A. (Sep 2007). „Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator”. Bioorganic and Medicinal Chemistry Letters 17 (17): 4855–60. DOI:10.1016/j.bmcl.2007.06.047. PMID 17604168. 
  7. ↑ Lysek, N; Rachor, E; Lindel, T (2002). „Isolation and structure elucidation of deformylflustrabromine from the North Sea bryozoan Flustra foliacea”. Z. Naturforsch., C, J. Biosci. 57 (11–12): 1056–61. PMID 12562094. 

Vanjske veze

Portal Medicina
Portal Hemija

Read other articles:

Turkey at the 1992 Summer Olympics

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Turkey at the 1992 Summer Olympics – news · newspapers · books · scholar · JSTOR (March 2023) (Learn how and when to remove this template message) Sporting event delegationTurkey at the1992 Summer OlympicsIOC codeTURNOCTurkish National Olympic CommitteeWebsiteo...

 

Milorad Dodik

Milorad Dodik Anggota Kepresidenan Bosnia dan Herzegovina dari Suku Serbia ke-10PetahanaMulai menjabat 20 November 2018Perdana MenteriDenis Zvizdić Zoran TegeltijaPendahuluMladen IvanićPenggantiPetahanaKetua Kepresidenan Bosnia dan HerzegovinaMasa jabatan20 November 2020 – 20 Juli 2021Perdana MenteriZoran TegeltijaPendahuluŠefik DžaferovićPenggantiŽeljko KomšićMasa jabatan20 November 2018 – 20 Juli 2019Perdana MenteriDenis ZvizdićPendahuluBakir IzetbegovićP...

 

Anthropology

Scientific study of humans, human behavior, and societies This article is about the study of humans. For the study of human origins, see Anthropogeny. For other uses, see Anthropology (disambiguation). An anthropologist with indigenous American people Part of a series onAnthropology OutlineHistory Types Archaeological Biological Cultural Linguistic Social Archaeological Aerial Aviation Battlefield Biblical Bioarchaeological Environmental Ethnoarchaeological Experiential Feminist Forensic Mari...

أكتروس

أكتروسمعلومات عامةالنوع truck model (en) موقع الويب mercedes-benz-trucks.com المنظومة الاقتصاديةالعلامة التجارية مرسيدس-بنز تعديل - تعديل مصدري - تعديل ويكي بيانات أكتروس (بالألمانية: Actros) هي شاحنة نقل ثقيلة من صنع شركة مرسيدس بنز الألمانية. تستخدم هذه الشاحنة لنقل البضائع والسلع وتاتي بمحر...

 

Tennis Borussia Berlin 2022-2023

Voce principale: Tennis Borussia Berlin. Tennis Borussia BerlinStagione 2022-2023Sport calcio Squadra TeBe Berlino Allenatore Abu Njie (1ª-16ª) Christopher Brauer (17ª-34ª) All. in seconda Stephan Kling Regionalliga18º posto Maggiori presenzeCampionato: Albers (30)Totale: Albers (30) Miglior marcatoreCampionato: Tekin (6)Totale: Tekin (6) StadioMommsenstadion Maggior numero di spettatori1 595 vs. Rot Weiss Erfurt Minor numero di spettatori312 vs. Meuselwitz Media spettatori757...

 

Baby Breeze

1965 studio album by Chet BakerBaby BreezeStudio album by Chet BakerReleased1965RecordedNovember 14 & 20, 1964StudioA&R Studios, NYCGenreJazzLength54:56 CD release with bonus tracksLabelLimelightLM 82003/LS 86003ProducerBobby ScottChet Baker chronology The Most Important Jazz Album of 1964/65(1964) Baby Breeze(1965) Stella by Starlight(1964) Baby Breeze is an album by trumpeter/vocalist Chet Baker which was recorded in 1964 and released on the Limelight label.[1][...

哈萨克斯坦总统

此条目序言章节没有充分总结全文内容要点。 (2019年3月21日)请考虑扩充序言，清晰概述条目所有重點。请在条目的讨论页讨论此问题。 哈萨克斯坦總統哈薩克總統旗現任Қасым-Жомарт Кемелұлы Тоқаев卡瑟姆若马尔特·托卡耶夫自2019年3月20日在任任期7年首任努尔苏丹·纳扎尔巴耶夫设立1990年4月24日（哈薩克蘇維埃社會主義共和國總統） 哈萨克斯坦 哈萨克斯坦政府...

 

Universal Music Group Nashville

US record company; Universal Music Group's country music subsidiary Universal Music Group NashvilleParent companyUniversal Music GroupFoundedMCA Nashville ( (1945-01-01) 1 January 1945 (age 79))Mercury Nashville ( (1945-01-01) 1 January 1945 (age 79))Capitol Nashville ( (1950-01-01) 1 January 1950 (age 74))Distributor(s)Universal Music DistributionGenreCountryCountry of originUnited StatesLocationNashville, TennesseeOfficial websiteumgnashville.com Universal Music Group Nashvil...

 

Gastric acid

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Gastric acid – news · newspapers · books · scholar · JSTOR (March 2022) (Learn how and when to remove this message)Digestive fluid formed in the stomach Determinants of gastric acid secretion Gastric acid or stomach acid is the acidic component – hydrochloric...

جايستور

جايستورالشعارمعلومات عامةموقع الويب jstor.org (الإنجليزية) نوع الموقع منظمة[1] — مكتبة رقمية — موقع ويب البلد الأصلي  الولايات المتحدة[1] التأسيس 1995 الجوانب التقنيةاللغة الإنجليزية ترتيب أليكسا 1٬138[2](18 مايو 2020) أهم الشخصياتالمالك إيثاكا هاربورز تعديل - تعديل مص�...

 

فلاديمير فورناليك

فلاديمير فورناليك   معلومات شخصية الميلاد 11 أبريل 1963 (العمر 61 سنة) الطول 1.73 م (5 قدم 8 بوصة) مركز اللعب مدافع الجنسية بولندا  المسيرة الاحترافية1 سنوات فريق م. (هـ.) 1982–1994 رتش شوروزو 233 (4) الفرق التي دربها 1996 Polonia Bytom [الإنجليزية]‏ 2001 غورنيك زابجه 2002–2004 غورنيك ز�...

 

3rd (City of London) Battalion, London Regiment

Not to be confused with the 3rd Battalion of The Royal Fusiliers (City of London Regiment). 20th Middlesex Rifle Volunteer Corps3rd City of London Regiment69th (3rd City of London) S/L Regiment625th Light Anti-Aircraft RegimentActive13 December 1859 – 10 March 1955Country United KingdomBranch Territorial ArmyRoleInfantryAir DefenceSize1 Battalion4 Battalions (WWI)3 Batteries (WWII)Part ofRoyal FusiliersLondon RegimentGarrison/HQ21 Edward Street, Hampstead Road, St Pancras (3rd Lo...

Diavolo

Disambiguazione – Se stai cercando altri significati, vedi Diavolo (disambigua). Disambiguazione – Diavoli rimanda qui. Se stai cercando altri significati, vedi Diavoli (disambigua). Il diavolo Lucifero immobilizzato al centro del Cocito, enorme lago ghiacciato situato sul fondo dell'Inferno della Divina Commedia (illustrazione di Gustave Doré) Nelle religioni il diavolo (o demonio o maligno) è un'entità spirituale o soprannaturale essenzialmente malvagia, distruttrice, menzog...

 

Pulal block

The Puzhal block is a revenue block in the Tiruvallur district of Tamil Nadu, India. It has a total of 7 panchayat villages. References Map of revenue blocks of Tiruvallur district. Government of Tamil Nadu. vteTiruvallur districtDistrict headquarters Tiruvallur Country India State Tamil Nadu Region Tondai Nadu Revenue divisions Ponneri Thiruvallur Tiruttani Taluks Avadi Gummidipoondi Pallipattu Ponneri Poonamallee RK Pet Tiruttani Tiruvallur Uthukkottai Revenue blocks Ellapuram Gummidipoond...

 

General Dynamics European Land Systems

This article relies excessively on references to primary sources. Please improve this article by adding secondary or tertiary sources. Find sources: General Dynamics European Land Systems – news · newspapers · books · scholar · JSTOR (September 2023) (Learn how and when to remove this message) General Dynamics European Land SystemsIndustryDefencePredecessor EWK [de] FWW Fahrzeugwerk GmbH Mowag AG Santa Bárbara Sistemas SA Steyr-Daimler-Pu...

Торбей

Торбей на карте Англии То́рбей[1] (англ. Torbay) — унитарная единица на юго-востоке церемониального графства Девон. Главный и крупнейший город — Торки (население — 64 тыс. чел.). Регион Торбей является популярным местом отдыха, его называют Английской Ривьеро...

 

Jim Tressel

American football coach (born 1952) Jim TresselTressel in 2009 while with Ohio State9th President ofYoungstown State UniversityIn officeMay 9, 2014 – February 1, 2023Preceded byRandy DunnSucceeded byBill Johnson Personal detailsBorn (1952-12-05) December 5, 1952 (age 71)Mentor, Ohio, U.S.SpouseEllen TresselChildren4EducationBaldwin-Wallace College (BA)University of Akron (MA)Coaching careerPlaying career1971–1974Baldwin-Wallace Position(s)QuarterbackCoaching career (HC unles...

 

Erik Waller (collector)

Swedish surgeon and book collector This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. Please help improve this article by introducing more precise citations. (January 2015) (Learn how and when to remove this message) Erik WallerBorn1875Died1955OccupationsurgeonKnown forbook collection Erik Waller (1875–1955) was a Swedish surgeon and book collector. Waller collected some 20,000 important ...

David Graeber

American anthropologist and activist (1961–2020) David GraeberGraeber in 2015BornDavid Rolfe Graeber(1961-02-12)February 12, 1961New York City, U.S.DiedSeptember 2, 2020(2020-09-02) (aged 59)Venice, ItalyAlma materState University of New York at Purchase (BA)University of Chicago (MA, PhD)Known forFragments of an Anarchist Anthropology (2004)Debt: The First 5000 Years (2011)The Utopia of Rules (2015)Bullshit Jobs (2018)The Dawn of Everything (2021)Spouse Nika Dubrovsky &#...

 

Cuesta

Pour les articles homonymes, voir Cuesta (homonymie) et Côte. Cet article est une ébauche concernant la géographie. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. La cuesta est une forme de relief dissymétrique constituée d’un côté par un talus à profil concave (le front), en pente raide et, de l’autre, par un plateau doucement incliné en sens inverse (le revers). Les cuestas se trouvent aux bordur...