Romifidin

Romifidin
(IUPAC) ime
N-(2-bromo-6-fluorofenil)-4,5-dihidro-1H-imidazol-2-amin
Klinički podaci
AHFS/Drugs.com Internacionalno ime leka
Identifikatori
CAS broj 65896-16-4
ATCvet kod QN05CM93
PubChem[1][2] 71969
UNII 876351L05K DaY
Hemijski podaci
Formula C9H9BrFN3 
Mol. masa 258,09
SMILES eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Veterinarska upotreba
Način primene IV

Romifidin je lek koji se koristi u veterini kao sedativ uglavnom za velike životinje kao što su konji,[3] mada se on može koristiti u širokom nizu vrsta.[4][5] On se ne koristi za ljude, ali je blisko strukturno srodan sa lekom u širokoj upotrebi klonidinom.

Romifidin deluje kao agonist na α2 adrenergičkom receptoru. Nuspojave mogu da obuhavataju bradikardiju i respiratornu depresiju. On se često koristi uporedo sa drugim sedativima ili analgeticima kao što je ketamin ili butorfanol.[6][7] Johimbin se može koristiti kao antidot za brzo poništanje njegovog dejstva.

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. American Journal of Veterinary Research. 2005 Nov;66(11):1992-8. PMID 16334961
  4. ↑ De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine. 2007 Feb;54(1):48-50. PMID 17359455
  5. ↑ Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. Veterinary Record. 2008 Jan 19;162(3):82-7. PMID 18204032
  6. ↑ Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Veterinary Anaesthesia and Analgesia. 2005 Jan;32(1):16-22. PMID 15663735
  7. ↑ Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. Canadian Journal of Veterinary Research. 2004 Oct;68(4):274-82. PMID 15581222

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