Flurazepam

Flurazepam
(IUPAC) ime
7-hloro-1-[2-(dietilamino)etil]-5-(2-fluorofenil)-1,3-dihidro-2H-1,4-benzodiazepin-2-on
Klinički podaci
Robne marke Dalmane
AHFS/Drugs.com Monografija
MedlinePlus a682051
Identifikatori
CAS broj 17617-23-1
ATC kod N05CD01
PubChem[1][2] 3393
DrugBank DB00690
ChemSpider[3] 3276
UNII IHP475989U DaY
KEGG[4] D00329 DaY
ChEMBL[5] CHEMBL968 DaY
Hemijski podaci
Formula C21H23ClFN3O 
Mol. masa 387,88 g/mol
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 79.5 °C (175 °F)
Farmakokinetički podaci
Bioraspoloživost 83%
Metabolizam Hepatički
Poluvreme eliminacije 40–250 sata
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Schedule IV (SAD)
Način primene Oralno

Flurazepam[6] (u prodaji pod imenima Dalmane i Dalmadorm) je lek iz benzodiazepinske klase. On poseduje anksiolitičkia, antikonvulsivna, sedativna i miorelaksantna svojstva. Iz flurazepama se formira metabolit sa veoma dugim poluživotom (40–250 sati), koji se može zadržati u krvi do četiri dana.[7] Flurazepam stoga nije podesan za primenu kao sredstvo za spavanje, jer uzrokuje sedaciju narednog dana, mada taj efekat može da olakša anksiozne poteškoće.[8][9][10][11][12][13][14]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ BE Patent 629005
  7. ↑ „Benzodiazepine Equivalence”. Arhivirano iz originala na datum 2007-07-17. Pristupljeno 2014-04-05. 
  8. ↑ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
  9. ↑ Vermeeren A: Residual effects of hypnotics: epidemiology and clinical implications. CNS Drugs. 2004;18(5):297-328. PMID 15089115
  10. ↑ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
  11. ↑ Rooke KC: The use of flurazepam (dalmane) as a substitute for barbiturates and methaqualone/diphenhydramine (mandrax) in general practice. J Int Med Res. 1976;4(5):355-9. PMID 18375
  12. ↑ Olive G, Dreux C: [Pharmacologic bases of use of benzodiazepines in pereinatal medicine] Arch Fr Pediatr. 1977 Jan;34(1):74-89. PMID 851373
  13. ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  14. ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

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