Nitrazepam

Nitrazepam
(IUPAC) ime
7-nitro-5-fenil-2,3-dihidro-1H-1,4-benzodiazepin-2-on
Klinički podaci
Robne marke Alodorm, Apo-nitrazepam tablets BP, Apodorm, Benzalin
AHFS/Drugs.com Monografija
Identifikatori
CAS broj 146-22-5
ATC kod N05CD03 , N05CD02
PubChem[1][2] 4506
DrugBank DB01595
ChemSpider[3] 4350
KEGG[4] C07487 DaY
Hemijski podaci
Formula C15H11N3O3 
Mol. masa 281.2661
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 225 °C (437 °F)
Farmakokinetički podaci
Poluvreme eliminacije 15-38 sati
Farmakoinformacioni podaci
Trudnoća ?
Pravni status
Način primene Oralno

Nitrazepam je benzodiazepinski derivat koji se koristi kao antikonvulsant i hipnotik.[5][6][7][8][9][10][11]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
  6. ↑ Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. PMID 7782744
  7. ↑ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
  8. ↑ Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. PMID 10877119
  9. ↑ Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. PMID 1676167
  10. ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  11. ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

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