Nebenzodiazepin

Nebenzodiazepini (ponekad se kolokvijalno nazivaju „Z-lekovi“) su klasa psihoaktivnih lekova koji su po prirodi veoma slični benzodiazepinima. Farmakodinamika nebenzodiazepina je skoro potpuno ista sa benzodiazepinskim lekovima i stoga oni imaju slične prednosti, nuspojave, i rizike. Nebenzodiazepini, međutim, imaju različite različite hemijske strukture i nisu srodni sa benzodiazepinima na molekulskom nivou.[1][2]

Klase

Strukture u osnovi nebenzodiazepina (leve tri slike) i strukture benzodiazepina (desno).

Trenutno, glavne hemijske klase nonbenzodiazepines su:

Imidazopiridini

Pirazolopirimidini

Reference

  1. ↑ Siriwardena AN, Qureshi Z, Gibson S, Collier S, Latham M (December 2006). „GPs' attitudes to benzodiazepine and 'Z-drug' prescribing: a barrier to implementation of evidence and guidance on hypnotics”. Br J Gen Pract 56 (533): 964–7. PMC 1934058. PMID 17132386. 
  2. ↑ Wagner J, Wagner ML, Hening WA (June 1998). „Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia”. Ann Pharmacother 32 (6): 680–91. DOI:10.1345/aph.17111. PMID 9640488. 

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