Estazolam

Estazolam
(IUPAC) ime
8-hloro-6-fenil-
4H-1,2,4-triazolo(4,3-a)-
1,4-benzodiazepin
Klinički podaci
AHFS/Drugs.com Monografija
MedlinePlus a691003
Identifikatori
CAS broj 29975-16-4
ATC kod N05CD04
PubChem[1][2] 3261
DrugBank DB01215
ChemSpider[3] 3146
UNII 36S3EQV54C DaY
KEGG[4] D00311 DaY
ChEBI CHEBI:4858 DaY
ChEMBL[5] CHEMBL285674 DaY
Hemijski podaci
Formula C16H11ClN4 
Mol. masa 294,7
SMILES eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost 93%
Metabolizam Hepatički
Poluvreme eliminacije 10-24 sata
Izlučivanje Renalno
Farmakoinformacioni podaci
Trudnoća ?
Pravni status Schedule IV (SAD)
Način primene Oralno

Estazolam[6] (ProSom, Eurodin) je benzodiazepinski derivat. Ovaj lek je razvilo preduzeće Upjohn tokom 1970-tih.[7] On poseduje anksiolitička, antikonvulsivna, sedativna i miorelaksantna svojstva. Estazolam je benzodiazepin srednje dužine dejstva.[8][9][10][11]

On se često propisuje za kratkotrajne tretmane insomnije.

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ US Patent 4116956
  7. ↑ US Patent 3701782 - 1-CARBOLOWER ALKOXY-6-PHENYL-4H-S-TRIAZOLO(1,4)BENZODIAZEPINE COMPOUNDS
  8. ↑ Watanabe S, Ohta H, Sakurai Y, Takao K, Ueki S: [Electroencephalographic effects of 450191-S and its metabolites in rabbits with chronic electrode implants] Nippon Yakurigaku Zasshi. 1986 Jul;88(1):19-32. PMID 3758874
  9. ↑ Oishi R, Nishibori M, Itoh Y, Saeki K: Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 1986 May 27;124(3):337-42. PMID 3089825
  10. ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682. 
  11. ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412. 

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