2-Metil-2-butanol

2-Metil-2-butanol
Stereo, skeletal formula of 2-methyl-2-butanol
Ball-and-stick model of 2-methyl-2-butanol
Ball-and-stick model of 2-methyl-2-butanol
Space-filling model of the 2-methyl-2-butanol
Space-filling model of the 2-methyl-2-butanol
Preferentno IUPAC ime

2-Metil-2-butanol[1]

Naziv po klasifikaciji 2-Metilbutan-2-ol[1]
Drugi nazivi terc-Amil alkohol[1]

Amylene hydrate[1]
Dimethylethylcarbinol[1]
tert-pentil alkohol[1]

Identifikacija
CAS registarski broj 75-85-4 DaY
PubChem[2][3] 6405
ChemSpider[4] 6165 DaY
UNII 69C393R11Z DaY
EINECS broj 200-908-9
UN broj 1105
KEGG[5] D02931
MeSH tert-amyl+alcohol
ChEMBL[6] CHEMBL44658 DaY
RTECS registarski broj toksičnosti SC0175000
Bajlštajn 1361351
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C5H12O
Molarna masa 88.15 g mol−1
Agregatno stanje Bezbojna tečnost
Miris miris kamfora, peperminta
Gustina 805 mg cm−3
Tačka topljenja

-9 °C, 264 K, 16 °F

Tačka ključanja

101-103 °C, 374-376 K, 214-217 °F

Rastvorljivost u vodi 120 g dm−3
log P 1,095
Napon pare 1,6 kPa (na 20 °C)
Indeks prelamanja (nD) 1,405
Termohemija
Standardna entalpija stvaranja jedinjenja ΔfHo298 −380,0–−379,0 kJ mol−1
Std entalpija
sagorevanja ΔcHo298 		−3,3036–−3.3026 MJ mol−1
Standardna molarna entropija So298 229,3 J K−1 mol−1
Opasnost
Podaci o bezbednosti prilikom rukovanja (MSDS) hazard.com
EU-klasifikacija Flammable F Harmful Xn
EU-indeks 603-007-00-2
NFPA 704
3
1
0
 
R-oznake R11, R20, R37/38
S-oznake S2, S46
Tačka paljenja 19 °C
Tačka spontanog paljenja 437 °C
Eksplozivni limiti 9%

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

2-Metil-2-butanol (terc-amil alkohol, 2M2B, amilen hidrat) je jedan od izomera amil alkohola. On je čista, bezbojna tečnost sa jakim mirisom peperminta ili kamfora.[7][8] Kod ljudi on ispoljava sedativno, hipnotičko, i antikonvulsivno dejstvo slično etanolu pri gutanju ili udisanju. Ranije je korišten u medicini za te svrhe.[9] On je aktivan u dozama u opsegu od 2.000-4.000 mg, te je 20 puta potentniji od etanol.a[10][11] Njegov hipnotički potencijal je između hloral hidrata i paraldehida.[12] In humans, 2-methyl-2-butanol is metabolized primarily via gluconoridation and oxidation to 2,3-dihydroxy-2-methylbutane.[13] Prekomerna doza proizvodi simptome slične alkoholnom trovanju.

Reference

  1. ↑ 1,0 1,1 1,2 1,3 1,4 1,5 „tert-amyl alcohol - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification and Related Records. Pristupljeno 13. 12. 2011. 
  2. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  3. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  4. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  5. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  6. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  7. ↑ Coblentz, Virgil (1899). The Newer Remedies: A reference manual for physicians, pharmacists, and students (3rd izd.). Philadelphia: P. Blakiston's Son & Co. str. 18. 
  8. ↑ H. C. Wood & R. M. Smith, ur. (1887-09-15). „Amylene hydrate - a new hypnotic”. Therapeutic Gazette - A monthly journal of physiological and clinical therapeutics (Detroit MI and Philadelpia PA: G. S. Davis) 3: 605–606. 
  9. ↑ Lewis, Robert A. (1998). Lewis' Dictionary of Toxicology. CRC Press. str. 45. ISBN 1-56670-223-2. 
  10. ↑ Hans Brandenberger & Robert A. A. Maes, ur. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. str. 401. ISBN 3-11-010731-7. 
  11. ↑ D. W. Yandell et al. (1888). „Amylene hydrate, a new hypnotic”. The American Practitioner and News (Lousville KY: John P. Morton & Co) 5: 88–89. 
  12. ↑ F. A. Castle & C. Rice (March 1888). „Amylene and amylene hydrate”. The American Druggist 17 (3): 58–59. 
  13. ↑ Collins, A. S.; Sumner, S. C.; Borghoff, S. J.; Medinsky, M. A. (1999). „A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures”. Toxicological sciences : an official journal of the Society of Toxicology 49 (1): 15–28. DOI:10.1093/toxsci/49.1.15. PMID 10367338. 

Literatura

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