Trimazosin

Trimazosin
(IUPAC) ime
(2-hidroksi-2-metilpropil) 4-(4-amino-6,7,8-trimetoksihinazolin-2-il)piperazin-1-karboksilat
Klinički podaci
Identifikatori
CAS broj 53746-46-6
ATC kod C02CA03
PubChem[1][2] 37264
UNII 31L760807H DaY
ChEMBL[3] CHEMBL513301 DaY
Hemijski podaci
Formula C20H29N5O6 
Mol. masa 435,47 g/mol
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Trimazosin je simpatomimetički lek. On je alfa blokator.[4]

Završni stupanj sinteze trimazosina je[5]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  4. ↑ van Kalken CK, van der Meulen J, Oe PL, Vriesendorp R, Donker AJ (1986). „Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension”. Eur. J. Clin. Pharmacol. 31 (1): 63–8. DOI:10.1007/BF00870988. PMID 3780829. 
  5. ↑ Hess, H. J.; 1972, U.S. Patent 3,669,968

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