7-OH-DPAT

7-OH-DPAT
Strukturna formula 7-OH-DPAT
IUPAC ime
Naziv po klasifikaciji 7-(Dipropilamino)-5,6,7,8-tetrahidronaftalen-2-ol[1]
Identifikacija
Abrevijacija 7-OH-DPAT
CAS registarski broj 74938-11-7 DaY
PubChem[2][3] 1219, 
6603867 (R), 
23928184 (S)
ChemSpider[4] 1182 DaY, 5036175 (R) DaY
MeSH 7-Hydroxy-2-N,N-dipropylaminotetralin
ChEMBL[5] CHEMBL285755 DaY
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C16H25NO
Molarna masa 247.38 g mol−1
log P 3,653
pKa 10,389
Baznost (pKb) 3,608

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

7-OH-DPAT je sintetičko jedinjenje koje deluje kao agonist dopaminskog receptora sa umerenom selektivnošću za D3 receptorski podtip,[6][7][8] i sa niskim afinitetom za serotoninske receptore, za razliku od njegovog strukturnog izomera 8-OH-DPAT.[9][10][11]

Reference

  1. ↑ 1,0 1,1 „7-hydroxy-2-N,N-dipropylaminotetralin - PubChem Public Chemical Database”. The PubChem Project. USA: National Center for Biotechnology Information. 
  2. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  3. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  4. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ Mulder TB, de Vries JB, Dijkstra D, Wiechers JW, Grol CJ, Horn AS (November 1987). „Further in vitro and in vivo studies with the putative presynaptic dopamine agonist N,N-dipropyl-7-hydroxy-2-aminotetralin”. Naunyn-Schmiedeberg's Archives of Pharmacology 336 (5): 494–501. PMID 2830544. 
  7. ↑ Lévesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P (September 1992). „Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3Hhydroxy-N,N-di-n-propyl-2-aminotetralin”]. Proceedings of the National Academy of Sciences of the United States of America 89 (17): 8155–9. DOI:10.1073/pnas.89.17.8155. PMC 49875. PMID 1518841. 
  8. ↑ Lévesque D (August 1996). „Aminotetralin drugs and D3 receptor functions. What may partially selective D3 receptor ligands tell us about dopamine D3 receptor functions?”. Biochemical Pharmacology 52 (4): 511–8. DOI:10.1016/0006-2952(96)00239-0. PMID 8759022. 
  9. ↑ Arvidsson LE, Johansson AM, Hacksell U, Nilsson JL, Svensson K, Hjorth S, Magnusson T, Carlsson A, Andersson B, Wikström H (November 1987). „(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist”. Journal of Medicinal Chemistry 30 (11): 2105–9. DOI:10.1021/jm00394a029. PMID 2959776. 
  10. ↑ Malmberg A, Nordvall G, Johansson AM, Mohell N, Hacksell U (August 1994). „Molecular basis for the binding of 2-aminotetralins to human dopamine D2A and D3 receptors”. Molecular Pharmacology 46 (2): 299–312. PMID 8078492. 
  11. ↑ Eltayb A, Lindblom S, Oerther S, Ahlenius S (July 2001). „Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat”. Acta Physiologica Scandinavica 172 (3): 205–9. DOI:10.1046/j.1365-201x.2001.00858.x. PMID 11472307. 

Povezano