Sigma-2 receptor

Sigma-2 receptor (σ2R) je sigma receptor koji preferentno vezuje siramesin[1] i PB28.[2]

Aktivacija ovog receptora može da uzrokuje apoptozu.[3] 3E farmakofor model sigma2 receptora baziran na seriji supstituisanih benzo[d]oksazol-2(3H)-on derivata je objavljen.[4]

Povezano

Literatura

  1. ↑ Skuza G, Rogóz Z (2006). „The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats”. J. Physiol. Pharmacol. 57 (2): 217–29. PMID 16845227. 
  2. ↑ Cassano G, Gasparre G, Contino M, et al (2006). „The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells”. Cell Calcium 40 (1): 23–8. DOI:10.1016/j.ceca.2006.03.004. PMID 16687172. 
  3. ↑ Bowen WD (March 2000). „Sigma receptors: recent advances and new clinical potentials”. Pharm Acta Helv 74 (2–3): 211–8. DOI:10.1016/S0031-6865(99)00034-5. PMID 10812960. 
  4. ↑ Laurini E, Zampieri D, Mamolo MG, Vio L, Zanette C, Florio C, Posocco P, Fermeglia M, Pricl S (May 2010). „A 3D-pharmacophore model for sigma2 receptors based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives”. Bioorg. Med. Chem. Lett. 20 (9): 2954–7. DOI:10.1016/j.bmcl.2010.03.009. PMID 20347592. 

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