PB28

PB-28
PB28
IUPAC ime
Drugi nazivi PB28
Identifikacija
CAS registarski broj 172906-90-0
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C24H38N2O
Molarna masa 370.57 g/mol

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

PB-28[1] je agonist sigma-2 receptora.[2][3][4][5][6]

On je izveden iz cikloheksil-piperazina.

Literatura

  1. Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). „New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives”. J. Med. Chem. 39 (1): 176–82. DOI:10.1021/jm950409c. PMID 8568804. 
  2. Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). „The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells”. Cell Calcium 40 (1): 23–8. DOI:10.1016/j.ceca.2006.03.004. PMID 16687172. 
  3. Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). „Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer”. Mol. Cancer Ther. 5 (7): 1807–16. DOI:10.1158/1535-7163.MCT-05-0402. PMID 16891467. 
  4. Colabufo NA, Berardi F, Abate C, Contino M, Niso M, Perrone R (July 2006). „Is the sigma2 receptor a histone binding protein?”. Journal of Medicinal Chemistry 49 (14): 4153–8. DOI:10.1021/jm0600592. PMID 16821775. 
  5. Berardi F, Abate C, Ferorelli S, Uricchio V, Colabufo NA, Niso M, Perrone R (December 2009). „Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)”. Journal of Medicinal Chemistry 52 (23): 7817–28. DOI:10.1021/jm9007505. PMID 19842660. 
  6. Abate C, Elenewski J, Niso M, Berardi F, Colabufo NA, Azzariti A, Perrone R, Glennon RA (February 2010). „Interaction of the sigma(2) receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer”. Chemmedchem 5 (2): 268–73. DOI:10.1002/cmdc.200900402. PMID 20077462. 

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