Integralni membranski protein

E = ekstracelularni prostor
P = membrana plazme
I = intracelularni prostor

Integralni membranski protein (IMP) je proteinski molekul (ili agregat proteina) koji je permanentno vezan za biološku membranu. Takvi proteini se mogu odvojiti od membrana samo putem deterđženata, nepolarnih rastvarača, ili u nekim slučajevima denaturirajućih agenasa.

Integralni membranski proteini sačinjavaju veoma značajnu frakciju proteina kodiranih genomom jednog organizma.[1]

Struktura

Tri-dimenzione strukture od samo ~160 različitih integralnih membranskih proteina su do sad određene u atomskoj rezoluciji putem kristalografije X-zracima ili nuklearne magnetne rezonancije usled poteškoća vezanih za ekstrakciju i kristalizaciju. Osim toga, strukture mnogih u vodi rastvornih domena su dostupne u proteinskoj banki podataka. Njihove za membranu vezujući α-heliksi su bili odstranjeni da bi se omogućila ekstrakcija i kristalizacija.

Povezano

Reference

  1. ↑ Wallin E, von Heijne G (1998). „Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms”. Protein Science 7 (4): 1029–38. DOI:10.1002/pro.5560070420. PMC 2143985. PMID 9568909. 

Literatura

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