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Protein toplotnog šoka 70 kDa 1A
	; PDB prikaz baziran na 1hjo.
Dostupne strukture
	1hjo, 1s3x, 1xqs
Identifikatori
Simboli	HSPA1A; HSP70-1; HSP72; HSPA1; HSPA1B; HSPA1A; HSP70-2
Vanjski ID	OMIM: 140550 MGI: 99517 HomoloGene: 74294 GeneCards: HSPA1A Gene
Ontologija gena
Molekularna funkcija	• vezivanje nukleotida; • ATP vezivanje; • vezivanje nesavijenog proteina;
Celularna komponenta	• jedro; • citoplazma; • mitohondrija; • endoplazmatični retikulum;
Biološki proces	• proteinsko savijanje; • respons na nesavijeni protein; • iRNK katabolički proces; • anti-apoptoza;
Ortolozi

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HSPA1A, protein toplotnog šoka 70 kDa 1, je protein koji je kod čoveka kodiran HSPA1A genom.

Ovaj gen ne sadrži introne. On je član familije proteina toplotnog šoka 70. Zajedno s drugim proteinima toplotnog šoka, ovaj protein sprečava agregaciju postojećih proteina i posreduje savijanje novo transliranih proteina u citosolu i organelama. On takođe učestvuje u ubikvitin-proteasom putu tako što ostvaruje interakcije sa AU-bogatim elementom RNK-vezujućeg proteina 1. Ovaj gen je lociran u regionu klase III glavnog histokompatibilnostnog kompleksa, u klasteru sa dva blisko srodna gena koji kodiraju slične proteine.^[1]

Interakcije

Za HSPA1A je bilo pokazano da interaguje sa ASK1,^[2] STUB1,^[3]^[4] MSR1,^[5] BAG3,^[6]^[7] Parkinovom ligazom,^[4] Fankonijeva anemija, komplementaciona grupa C,^[8]^[9] GPR37,^[4] HSF1^[10]^[11] i AIFM1.^[12]^[13]

Reference

↑ „Entrez Gene: HSPA1A heat shock 70kDa protein 1A”.
↑ Park, Hee-Sae; Cho Ssang-Goo, Kim Chang Kyun, Hwang Hyun Sub, Noh Kyung Tae, Kim Mi-Sung, Huh Sung-Ho, Kim Myung Jin, Ryoo Kanghyun, Kim Eun Kyung, Kang Woo Jin, Lee Jae-Seon, Seo Jeong-Sun, Ko Young-Gyu, Kim Sunghoon, Choi Eui-Ju (November 2002). „Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1”. Mol. Cell. Biol. (United States) 22 (22): 7721–30. DOI:10.1128/MCB.22.22.7721-7730.2002. ISSN 0270-7306. PMC 134722. PMID 12391142.
↑ Ballinger, C A; Connell P, Wu Y, Hu Z, Thompson L J, Yin L Y, Patterson C (June 1999). „Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Mol. Cell. Biol. (UNITED STATES) 19 (6): 4535–45. ISSN 0270-7306. PMC 104411. PMID 10330192.
↑ ^4,0 ^4,1 ^4,2 Imai, Yuzuru; Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke (July 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell (United States) 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. ISSN 1097-2765. PMID 12150907.
↑ Nakamura, Toshinobu; Hinagata Jun-ichi, Tanaka Toshiki, Imanishi Takeshi, Wada Youichiro, Kodama Tatsuhiko, Doi Takefumi (January 2002). „HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors”. Biochem. Biophys. Res. Commun. (United States) 290 (2): 858–64. DOI:10.1006/bbrc.2001.6271. ISSN 0006-291X. PMID 11785981.
↑ Doong, H; Price J, Kim Y S, Gasbarre C, Probst J, Liotta L A, Blanchette J, Rizzo K, Kohn E (September 2000). „CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70”. Oncogene (ENGLAND) 19 (38): 4385–95. DOI:10.1038/sj.onc.1203797. ISSN 0950-9232. PMID 10980614.
↑ Antoku, K; Maser R S, Scully W J, Delach S M, Johnson D E (September 2001). „Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein”. Biochem. Biophys. Res. Commun. (United States) 286 (5): 1003–10. DOI:10.1006/bbrc.2001.5512. ISSN 0006-291X. PMID 11527400.
↑ Pang, Qishen; Christianson Tracy A, Keeble Winifred, Koretsky Tara, Bagby Grover C (December 2002). „The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC”. J. Biol. Chem. (United States) 277 (51): 49638–43. DOI:10.1074/jbc.M209386200. ISSN 0021-9258. PMID 12397061.
↑ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (October 2003). „Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport”. Exp. Cell Res. (United States) 289 (2): 211–21. DOI:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622.
↑ Shi, Y; Mosser D D, Morimoto R I (March 1998). „Molecular chaperones as HSF1-specific transcriptional repressors”. Genes Dev. (UNITED STATES) 12 (5): 654–66. ISSN 0890-9369. PMC 316571. PMID 9499401.
↑ Zhou, X; Tron V A, Li G, Trotter M J (August 1998). „Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light”. J. Invest. Dermatol. (UNITED STATES) 111 (2): 194–8. DOI:10.1046/j.1523-1747.1998.00266.x. ISSN 0022-202X. PMID 9699716.
↑ Ruchalski, Kathleen; Mao Haiping, Singh Satish K, Wang Yihan, Mosser Dick D, Li Fanghong, Schwartz John H, Borkan Steven C (December 2003). „HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells”. Am. J. Physiol., Cell Physiol. (United States) 285 (6): C1483–93. DOI:10.1152/ajpcell.00049.2003. ISSN 0363-6143. PMID 12930708.
↑ Ravagnan, L; Gurbuxani S, Susin S A, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger J M, Garrido C, Kroemer G (September 2001). „Heat-shock protein 70 antagonizes apoptosis-inducing factor”. Nat. Cell Biol. (England) 3 (9): 839–43. DOI:10.1038/ncb0901-839. ISSN 1465-7392. PMID 11533664.

Literatura

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Zhao RY, Bukrinsky M, Elder RT (2005). „HIV-1 viral protein R (Vpr) & host cellular responses.”. Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
Muthumani K, Choo AY, Premkumar A, et al. (2006). „Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism.”. Cell Death Differ.. 12 Suppl 1: 962–70. DOI:10.1038/sj.cdd.4401583. PMID 15832179.
Grosz MD, Womack JE, Skow LC (1993). „Syntenic conservation of HSP70 genes in cattle and humans.”. Genomics 14 (4): 863–8. DOI:10.1016/S0888-7543(05)80106-5. PMID 1478667.
Veldscholte J, Berrevoets CA, Brinkmann AO, et al. (1992). „Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation.”. Biochemistry 31 (8): 2393–9. DOI:10.1021/bi00123a026. PMID 1540595.
Abravaya K, Myers MP, Murphy SP, Morimoto RI (1992). „The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.”. Genes Dev. 6 (7): 1153–64. DOI:10.1101/gad.6.7.1153. PMID 1628823.
Milner CM, Campbell RD (1990). „Structure and expression of the three MHC-linked HSP70 genes.”. Immunogenetics 32 (4): 242–51. DOI:10.1007/BF00187095. PMID 1700760.
Sargent CA, Dunham I, Trowsdale J, Campbell RD (1989). „Human major histocompatibility complex contains genes for the major heat shock protein HSP70.”. Proc. Natl. Acad. Sci. U.S.A. 86 (6): 1968–72. DOI:10.1073/pnas.86.6.1968. PMC 286826. PMID 2538825.
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Goate AM, Cooper DN, Hall C, et al. (1987). „Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis.”. Hum. Genet. 75 (2): 123–8. DOI:10.1007/BF00591072. PMID 2880793.
Hickey E, Brandon SE, Sadis S, et al. (1986). „Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia.”. Gene 43 (1-2): 147–54. DOI:10.1016/0378-1119(86)90018-1. PMID 3019832.
Harrison GS, Drabkin HA, Kao FT, et al. (1987). „Chromosomal location of human genes encoding major heat-shock protein HSP70.”. Somat. Cell Mol. Genet. 13 (2): 119–30. DOI:10.1007/BF01534692. PMID 3470951.
Drabent B, Genthe A, Benecke BJ (1987). „In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.”. Nucleic Acids Res. 14 (22): 8933–48. DOI:10.1093/nar/14.22.8933. PMC 311921. PMID 3786141.
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Selkirk JK, Merrick BA, Stackhouse BL, He C (1995). „Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line.”. Appl. Theor. Electrophor. 4 (1): 11–8. PMID 7811761.
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Povezano

Vanjske veze

MeSH HSPA1A+protein,+human

[entrez-1] „Entrez Gene: HSPA1A heat shock 70kDa protein 1A”.

[pmid12391142-2] Park, Hee-Sae; Cho Ssang-Goo, Kim Chang Kyun, Hwang Hyun Sub, Noh Kyung Tae, Kim Mi-Sung, Huh Sung-Ho, Kim Myung Jin, Ryoo Kanghyun, Kim Eun Kyung, Kang Woo Jin, Lee Jae-Seon, Seo Jeong-Sun, Ko Young-Gyu, Kim Sunghoon, Choi Eui-Ju (November 2002). „Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1”. Mol. Cell. Biol. (United States) 22 (22): 7721–30. DOI:10.1128/MCB.22.22.7721-7730.2002. ISSN 0270-7306. PMC 134722. PMID 12391142.

[pmid10330192-3] Ballinger, C A; Connell P, Wu Y, Hu Z, Thompson L J, Yin L Y, Patterson C (June 1999). „Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions”. Mol. Cell. Biol. (UNITED STATES) 19 (6): 4535–45. ISSN 0270-7306. PMC 104411. PMID 10330192.

[pmid12150907-4] 4,0 ^4,1 ^4,2 Imai, Yuzuru; Soda Mariko, Hatakeyama Shigetsugu, Akagi Takumi, Hashikawa Tsutomu, Nakayama Kei Ichi, Takahashi Ryosuke (July 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell (United States) 10 (1): 55–67. DOI:10.1016/S1097-2765(02)00583-X. ISSN 1097-2765. PMID 12150907.

[pmid11785981-5] Nakamura, Toshinobu; Hinagata Jun-ichi, Tanaka Toshiki, Imanishi Takeshi, Wada Youichiro, Kodama Tatsuhiko, Doi Takefumi (January 2002). „HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors”. Biochem. Biophys. Res. Commun. (United States) 290 (2): 858–64. DOI:10.1006/bbrc.2001.6271. ISSN 0006-291X. PMID 11785981.

[pmid10980614-6] Doong, H; Price J, Kim Y S, Gasbarre C, Probst J, Liotta L A, Blanchette J, Rizzo K, Kohn E (September 2000). „CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70”. Oncogene (ENGLAND) 19 (38): 4385–95. DOI:10.1038/sj.onc.1203797. ISSN 0950-9232. PMID 10980614.

[pmid11527400-7] Antoku, K; Maser R S, Scully W J, Delach S M, Johnson D E (September 2001). „Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein”. Biochem. Biophys. Res. Commun. (United States) 286 (5): 1003–10. DOI:10.1006/bbrc.2001.5512. ISSN 0006-291X. PMID 11527400.

[pmid12397061-8] Pang, Qishen; Christianson Tracy A, Keeble Winifred, Koretsky Tara, Bagby Grover C (December 2002). „The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC”. J. Biol. Chem. (United States) 277 (51): 49638–43. DOI:10.1074/jbc.M209386200. ISSN 0021-9258. PMID 12397061.

[pmid14499622-9] Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J (October 2003). „Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport”. Exp. Cell Res. (United States) 289 (2): 211–21. DOI:10.1016/S0014-4827(03)00261-1. ISSN 0014-4827. PMID 14499622.

[pmid9499401-10] Shi, Y; Mosser D D, Morimoto R I (March 1998). „Molecular chaperones as HSF1-specific transcriptional repressors”. Genes Dev. (UNITED STATES) 12 (5): 654–66. ISSN 0890-9369. PMC 316571. PMID 9499401.

[pmid9699716-11] Zhou, X; Tron V A, Li G, Trotter M J (August 1998). „Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light”. J. Invest. Dermatol. (UNITED STATES) 111 (2): 194–8. DOI:10.1046/j.1523-1747.1998.00266.x. ISSN 0022-202X. PMID 9699716.

[pmid12930708-12] Ruchalski, Kathleen; Mao Haiping, Singh Satish K, Wang Yihan, Mosser Dick D, Li Fanghong, Schwartz John H, Borkan Steven C (December 2003). „HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells”. Am. J. Physiol., Cell Physiol. (United States) 285 (6): C1483–93. DOI:10.1152/ajpcell.00049.2003. ISSN 0363-6143. PMID 12930708.

[pmid11533664-13] Ravagnan, L; Gurbuxani S, Susin S A, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger J M, Garrido C, Kroemer G (September 2001). „Heat-shock protein 70 antagonizes apoptosis-inducing factor”. Nat. Cell Biol. (England) 3 (9): 839–43. DOI:10.1038/ncb0901-839. ISSN 1465-7392. PMID 11533664.

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